Polyunsaturated Fatty Acids Level and Bone Mineral Density: A Two-Sample Mendelian Randomization Study.
Front Endocrinol (Lausanne)
; 13: 858851, 2022.
Article
em En
| MEDLINE
| ID: mdl-35872990
ABSTRACT
Background:
This Mendelian randomization (MR) study aimed to explore the causal relationship between polyunsaturated fatty acids (PUFAs) and bone mineral density (BMD).Methods:
We conducted a two-sample MR analysis to figure out if there is any causal effect of PUFAs on BMD through the summary data from the genome-wide association study (GWAS). Relationships were evaluated through inverse variance weighted (IVW), MR-Egger, weighted median, and maximum likelihood methods. The MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) test was performed to detect the horizontal pleiotropy.Results:
Our findings revealed that omega-6 fatty acids were negatively related to the TB-BMD (beta-estimate -0.0515; 95% confidence interval [CI] -0.0911 to -0.0119; standard error [SE] 0.0201; p-value 0.0106). The reverse direction MR analysis showed that TB-BMD was linked to the omega-6 FAs (beta-estimate -0.0699; 95% CI -0.1304 to -0.0095; SE 0.0308; p-value 0.0265). No statistically significant correlations between PUFAs and BMD were observed after adjusting the interactions between metabolites.Conclusion:
This two-sample MR analyses produced strong and new genomic evidence that there was a causal relationship between omega-6 FAs and BMD. Further investigations are still required to elucidate the potential mechanism.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Densidade Óssea
/
Análise da Randomização Mendeliana
Tipo de estudo:
Clinical_trials
Idioma:
En
Revista:
Front Endocrinol (Lausanne)
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China