Bioactivation and reactivity research advances - 2021 year in review.
Drug Metab Rev
; 54(3): 246-281, 2022 08.
Article
em En
| MEDLINE
| ID: mdl-35876116
ABSTRACT
This year's review on bioactivation and reactivity began as a part of the annual review on biotransformation and bioactivation led by Cyrus Khojasteh (see references). Increased contributions from experts in the field led to the development of a stand alone edition for the first time this year focused specifically on bioactivation and reactivity. Our objective for this review is to highlight and share articles which we deem influential and significant regarding the development of covalent inhibitors, mechanisms of reactive metabolite formation, enzyme inactivation, and drug safety. Based on the selected articles, we created two sections (1) reactivity and enzyme inactivation, and (2) bioactivation mechanisms and safety (Table 1). Several biotransformation experts have contributed to this effort from academic and industry settings.[Table see text].
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Microssomos Hepáticos
Limite:
Humans
Idioma:
En
Revista:
Drug Metab Rev
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Estados Unidos