Spray-Dried and Spray-Freeze-Dried Powder Formulations of an Anti-Interleukin-4R&#945; Antibody for Pulmonary Delivery.

Pan, Harry W; Seow, Han Cong; Lo, Jason C K; Guo, Jinlin; Zhu, Lingqiao; Leung, Susan W S; Zhang, Chenghai; Lam, Jenny K W

Spray-Dried and Spray-Freeze-Dried Powder Formulations of an Anti-Interleukin-4Rα Antibody for Pulmonary Delivery.

Pan, Harry W; Seow, Han Cong; Lo, Jason C K; Guo, Jinlin; Zhu, Lingqiao; Leung, Susan W S; Zhang, Chenghai; Lam, Jenny K W.

Afiliação

Pan HW; Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, SAR.
Seow HC; Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, SAR.
Lo JCK; Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, SAR.
Guo J; R&D Department, Shanghai MabGeek Biotech Co. Ltd., Room 304, No. 1011 Halei Road, Zhangjiang Hi-tech Park, Shanghai, 201203, People's Republic of China.
Zhu L; R&D Department, Shanghai MabGeek Biotech Co. Ltd., Room 304, No. 1011 Halei Road, Zhangjiang Hi-tech Park, Shanghai, 201203, People's Republic of China.
Leung SWS; Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, SAR.
Zhang C; R&D Department, Shanghai MabGeek Biotech Co. Ltd., Room 304, No. 1011 Halei Road, Zhangjiang Hi-tech Park, Shanghai, 201203, People's Republic of China. chenghai.zhang@mabgeek.com.
Lam JKW; Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, SAR. jkwlam@hku.hk.

Pharm Res ; 39(9): 2291-2304, 2022 Sep.

Article em En | MEDLINE | ID: mdl-35879500

Assuntos

Asma; Aerossóis e Gotículas Respiratórios; 2-Hidroxipropil-beta-Ciclodextrina; Administração por Inalação; Anticorpos Monoclonais/química; Asma/tratamento farmacológico; Inaladores de Pó Seco; Liofilização/métodos; Humanos; Tamanho da Partícula; Pós/química

Palavras-chave

Asthma; inhalation; spray drying; spray freeze drying; therapeutic antibody

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Asma / Aerossóis e Gotículas Respiratórios Limite: Humans Idioma: En Revista: Pharm Res Ano de publicação: 2022 Tipo de documento: Article

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