Clinical, Endocrine and Neuroimaging Findings in Girls With Central Precocious Puberty.
J Clin Endocrinol Metab
; 107(10): e4132-e4143, 2022 09 28.
Article
em En
| MEDLINE
| ID: mdl-35881919
ABSTRACT
CONTEXT The etiology of central precocious puberty (CPP) includes a spectrum of conditions. Girls younger than age 6 years with CPP should undergo cranial magnetic resonance imaging (MRI), but it remains controversial whether all girls who develop CPP between the ages of 6 and 8 years require neuroimaging examination. OBJECTIVE:
To investigate the frequency of brain MRI abnormalities in girls diagnosed with CPP and the relationship between maternal factors, their age at presentation, clinical signs and symptoms, hormonal profiles, and neuroimaging findings.METHODS:
Data were collected between January 2005 and September 2019 from 112 girls who showed clinical pubertal progression before 8 years of age who underwent brain MRI.RESULTS:
MRI was normal in 47 (42%) idiopathic (I) scans, 54 (48%) patients had hypothalamic-pituitary anomalies (HPA) and/or extra-HP anomalies (EHPA), and 11 (10%) had brain tumors or tumor-like conditions (BT/TL), including 3 with neurological signs. Associated preexisting disorders were documented in 16. Girls with BT/TL had a higher LH peak after GnRH test (Pâ =â 0.01) than I, and those older than age 6 years had a higher craniocaudal diameter of the pituitary gland (Pâ =â 0.01); their baseline FSH and LH (Pâ =â 0.004) and peak FSH (Pâ =â 0.01) and LH (Pâ =â 0.05) values were higher than I. Logistic regression showed maternal age at menarche (Pâ =â 0.02) and peak FSH (Pâ =â 0.02) as BT/TL risk factors.CONCLUSIONS:
MRI provides valuable information in girls with CPP by demonstrating that fewer than half have a normal brain MRI and that few can have significant intracranial lesions after the age of 6, despite the absence of suggestive neurological signs.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Puberdade Precoce
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Neoplasias Encefálicas
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Risk_factors_studies
Limite:
Child
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Female
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Humans
Idioma:
En
Revista:
J Clin Endocrinol Metab
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Itália