The Increase in the Drug Resistance of Acute Myeloid Leukemia THP-1 Cells in High-Density Cell Culture Is Associated with Inflammatory-like Activation and Anti-Apoptotic Bcl-2 Proteins.

Kobyakova, Margarita; Lomovskaya, Yana; Senotov, Anatoly; Lomovsky, Alexey; Minaychev, Vladislav; Fadeeva, Irina; Shtatnova, Daria; Krasnov, Kirill; Zvyagina, Alena; Odinokova, Irina; Akatov, Vladimir; Fadeev, Roman

Kobyakova, Margarita; Lomovskaya, Yana; Senotov, Anatoly; Lomovsky, Alexey; Minaychev, Vladislav; Fadeeva, Irina; Shtatnova, Daria; Krasnov, Kirill; Zvyagina, Alena; Odinokova, Irina; Akatov, Vladimir; Fadeev, Roman.

Afiliação

Kobyakova M; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia.
Lomovskaya Y; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia.
Senotov A; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia.
Lomovsky A; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia.
Minaychev V; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia.
Fadeeva I; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia.
Shtatnova D; Pushchino State Institute of Natural Science, 142290 Pushchino, Moscow Region, Russia.
Krasnov K; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia.
Zvyagina A; Pushchino State Institute of Natural Science, 142290 Pushchino, Moscow Region, Russia.
Odinokova I; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia.
Akatov V; Pushchino State Institute of Natural Science, 142290 Pushchino, Moscow Region, Russia.
Fadeev R; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia.

Int J Mol Sci ; 23(14)2022 Jul 17.

Article em En | MEDLINE | ID: mdl-35887226

Assuntos

Proteínas Reguladoras de Apoptose; Leucemia Mieloide Aguda; Apoptose; Técnicas de Cultura de Células; Linhagem Celular Tumoral; Resistência a Medicamentos; Resistencia a Medicamentos Antineoplásicos; Humanos; Leucemia Mieloide Aguda/tratamento farmacológico; Leucemia Mieloide Aguda/metabolismo; NF-kappa B; Proteínas Proto-Oncogênicas c-bcl-2/genética; Proteínas Proto-Oncogênicas c-bcl-2/metabolismo; Células THP-1

Palavras-chave

DNA-damaging drugs; acute myeloid leukemia; drug resistance; high-density cell culture; inflammation; izTRAIL

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Proteínas Reguladoras de Apoptose Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Federação Russa

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