Mesenchymal stromal cells as a tool to unravel the developmental origins of disease.
Trends Endocrinol Metab
; 33(9): 614-627, 2022 09.
Article
em En
| MEDLINE
| ID: mdl-35902331
ABSTRACT
The intrauterine environment can induce alterations of the epigenome that have a lasting impact on disease risk. Current human studies in the field focus on a single epigenetic mark, DNA methylation, measured in blood. For in-depth mechanistic insight into the developmental origins of disease, it will be crucial to consider innovative tissue types. Mesenchymal stromal cells (MSCs) may serve as a novel tool to investigate the full epigenome beyond DNA methylation, to explore other omics levels, and to perform functional assays. Moreover, MSCs can be differentiated into multiple cell types and thereby mimic otherwise inaccessible cell types. A first wave of studies supports the potential of MSCs and illustrates how the innovative use of this cell type may be incorporated in birth cohorts.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Epigênese Genética
/
Células-Tronco Mesenquimais
Limite:
Humans
Idioma:
En
Revista:
Trends Endocrinol Metab
Assunto da revista:
ENDOCRINOLOGIA
/
METABOLISMO
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Holanda