Your browser doesn't support javascript.
loading
BDNF Alleviates Microglial Inhibition and Stereotypic Behaviors in a Mouse Model of Obsessive-Compulsive Disorder.
Luo, Yuchong; Chen, Xiao; Wei, Chunren; Zhang, Hongyang; Zhang, Lingyi; Han, Lu; Sun, Ke; Li, Boxing; Wen, Shenglin.
Afiliação
  • Luo Y; Department of Psychology, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China.
  • Chen X; Department of Psychology, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China.
  • Wei C; Department of Psychology, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China.
  • Zhang H; Guangdong Provincial Key Laboratory of Brain Function and Disease, Neuroscience Program, Zhongshan School of Medicine and the Fifth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
  • Zhang L; Guangdong Provincial Key Laboratory of Brain Function and Disease, Neuroscience Program, Zhongshan School of Medicine and the Fifth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
  • Han L; Guangdong Provincial Key Laboratory of Brain Function and Disease, Neuroscience Program, Zhongshan School of Medicine and the Fifth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
  • Sun K; Department of Burn and Plastic Surgery, People's Liberation Army of China Rocket Force Characteristic Medical Center, Beijing, China.
  • Li B; Guangdong Provincial Key Laboratory of Brain Function and Disease, Neuroscience Program, Zhongshan School of Medicine and the Fifth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
  • Wen S; Department of Psychology, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China.
Front Mol Neurosci ; 15: 926572, 2022.
Article em En | MEDLINE | ID: mdl-35909449
Obsessive-compulsive disorder (OCD) is a severe mental illness characterized by obsessions and compulsions. However, its underlying mechanisms remain to be elucidated. Recent studies have suggested that neuroimmune dysregulation is involved in the pathogenesis of OCD. To investigate the role of microglia in this disorder, we established a pharmacological mouse model by using the serotonin (5-HT) 1A/1B receptor agonist RU24969 to mimic monoamine dysregulation in OCD, and we examined the morphological and functional alterations of microglia in this model. We found that RU24969 treatment led to compulsive circling behavior in mice. Strikingly, we found that the density and mobility of microglia in the prelimbic cortex were much lower in RU24969-treated mice than in control mice. Moreover, the expression of cytokines and chemokines, including BDNF, IL-1ß, IL-6, TNFα, CD80, CD86, MHC-I, and MHC-II, also decreased in RU24969-treated mice. Importantly, we found that injection of BDNF or induction of BDNF expression by trehalose completely reversed microglial dysfunction and reduced stereotypic behavior. These results indicate that microglial dysfunction is closely related to stereotypic behaviors in our mouse model of OCD and that BDNF could be an effective treatment for stereotypic behaviors.
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Front Mol Neurosci Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Front Mol Neurosci Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China