A Principal Component Informed Approach to Address Polygenic Risk Score Transferability Across European Cohorts.

Pärna, Katri; Nolte, Ilja M; Snieder, Harold; Fischer, Krista; Marnetto, Davide; Pagani, Luca

Pärna, Katri; Nolte, Ilja M; Snieder, Harold; Fischer, Krista; Marnetto, Davide; Pagani, Luca.

Afiliação

Pärna K; Institute of Genomics, University of Tartu, Tartu, Estonia.
Nolte IM; Department of Epidemiology, University of Groningen, Groningen, Netherlands.
Snieder H; Department of Epidemiology, University of Groningen, Groningen, Netherlands.
Fischer K; Department of Epidemiology, University of Groningen, Groningen, Netherlands.
Marnetto D; Institute of Mathematics and Statistics, University of Tartu, Tartu, Estonia.

Front Genet ; 13: 899523, 2022.

Article em En | MEDLINE | ID: mdl-35923706

Palavras-chave

genome-wide association study; polygenic risk score; population structure; principal component analysis; transferability

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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Front Genet Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estônia

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