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Serine metabolism remodeling after platinum-based chemotherapy identifies vulnerabilities in a subgroup of resistant ovarian cancers.
Van Nyen, Tom; Planque, Mélanie; van Wagensveld, Lilian; Duarte, Joao A G; Zaal, Esther A; Talebi, Ali; Rossi, Matteo; Körner, Pierre-René; Rizzotto, Lara; Moens, Stijn; De Wispelaere, Wout; Baiden-Amissah, Regina E M; Sonke, Gabe S; Horlings, Hugo M; Eelen, Guy; Berardi, Emanuele; Swinnen, Johannes V; Berkers, Celia R; Carmeliet, Peter; Lambrechts, Diether; Davidson, Ben; Agami, Reuven; Fendt, Sarah-Maria; Annibali, Daniela; Amant, Frédéric.
Afiliação
  • Van Nyen T; Gynecological Oncology Laboratory, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), 3000, Leuven, Belgium.
  • Planque M; Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands.
  • van Wagensveld L; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Herestraat 49, 3000, Leuven, Belgium.
  • Duarte JAG; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Herestraat 49, 3000, Leuven, Belgium.
  • Zaal EA; Department of Obstetrics and Gynecology, Maastricht University Medical Centre, Maastricht, The Netherlands.
  • Talebi A; GROW, School for Oncology and Developmental Biology, Maastricht, The Netherlands.
  • Rossi M; Department of Research, Netherlands Comprehensive Cancer Organization (IKNL), Utrecht, The Netherlands.
  • Körner PR; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Herestraat 49, 3000, Leuven, Belgium.
  • Rizzotto L; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Herestraat 49, 3000, Leuven, Belgium.
  • Moens S; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research, Utrecht University, 3584 CH, Utrecht, The Netherlands.
  • De Wispelaere W; Division of Cell Biology, Metabolism and Cancer, Department Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, 3584 CL, Utrecht, The Netherlands.
  • Baiden-Amissah REM; Laboratory of Lipid Metabolism and Cancer, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), 3000, Leuven, Belgium.
  • Sonke GS; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Herestraat 49, 3000, Leuven, Belgium.
  • Horlings HM; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Herestraat 49, 3000, Leuven, Belgium.
  • Eelen G; Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands.
  • Berardi E; TRACE PDX Platform, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), 3000, Leuven, Belgium.
  • Swinnen JV; Gynecological Oncology Laboratory, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), 3000, Leuven, Belgium.
  • Berkers CR; Gynecological Oncology Laboratory, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), 3000, Leuven, Belgium.
  • Carmeliet P; Gynecological Oncology Laboratory, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), 3000, Leuven, Belgium.
  • Lambrechts D; Department of Medical Oncology, The Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands.
  • Davidson B; Division of Molecular Pathology, The Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands.
  • Agami R; Laboratory of Angiogenesis and Vascular Metabolism, VIB-KU Leuven Center for Cancer Biology, VIB, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), 3000, Leuven, Belgium.
  • Fendt SM; Department of Development and Regeneration, KU Leuven, 3000, Leuven, Belgium.
  • Annibali D; Laboratory of Lipid Metabolism and Cancer, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), 3000, Leuven, Belgium.
  • Amant F; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research, Utrecht University, 3584 CH, Utrecht, The Netherlands.
Nat Commun ; 13(1): 4578, 2022 08 05.
Article em En | MEDLINE | ID: mdl-35931688
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Platina Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Bélgica
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Platina Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Bélgica