Insight into Viral Hijacking of CRL4 Ubiquitin Ligase through Structural Analysis of the pUL145-DDB1 Complex.

Wick, Elizaveta T; Treadway, Colton J; Li, Zhijun; Nicely, Nathan I; Ren, Zhizhong; Baldwin, Albert S; Xiong, Yue; Harrison, Joseph S; Brown, Nicholas G

Wick, Elizaveta T; Treadway, Colton J; Li, Zhijun; Nicely, Nathan I; Ren, Zhizhong; Baldwin, Albert S; Xiong, Yue; Harrison, Joseph S; Brown, Nicholas G.

Afiliação

Wick ET; Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina, USA.
Treadway CJ; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hillgrid.10698.36, Chapel Hill, North Carolina, USA.
Li Z; Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina, USA.
Nicely NI; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hillgrid.10698.36, Chapel Hill, North Carolina, USA.
Ren Z; Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina, USA.
Baldwin AS; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hillgrid.10698.36, Chapel Hill, North Carolina, USA.
Xiong Y; Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina, USA.
Harrison JS; Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina, USA.
Brown NG; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hillgrid.10698.36, Chapel Hill, North Carolina, USA.

J Virol ; 96(17): e0082622, 2022 09 14.

Article em En | MEDLINE | ID: mdl-35938868

Assuntos

Proteínas Culina; Infecções por Citomegalovirus; Proteínas de Ligação a DNA; Proteínas Virais; Proteínas Culina/metabolismo; Infecções por Citomegalovirus/imunologia; Proteínas de Ligação a DNA/metabolismo; Humanos; Ligação Proteica; Conformação Proteica; Fator de Transcrição STAT2/metabolismo; Complexos Ubiquitina-Proteína Ligase/metabolismo; Proteínas Virais/metabolismo

Palavras-chave

cullin-RING; human cytomegalovirus; innate immunity; ubiquitin ligase; viral hijacking

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Virais / Infecções por Citomegalovirus / Proteínas Culina / Proteínas de Ligação a DNA Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Virol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

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