Semantic processing and neurobiology in Alzheimer's disease and Mild Cognitive Impairment.
Neuropsychologia
; 174: 108337, 2022 09 09.
Article
em En
| MEDLINE
| ID: mdl-35940277
ABSTRACT
In the present theoretical review we will perform a critical surveillance of linguistic and semantic processing in Mild Cognitive Impairment and Alzheimer's disease, explicitly favouring a neurobiological prism. We conjecture that most linguistic alterations arise from semantic indiscrimination through inhibitory hypofunction. Specifically, a conjoint cluster of cholinergic dysfunction, Aß load and somatostatin-positive cell loss renders the semantic network disinhibited and overly noisy fine discriminatory processes in temporal and medial-frontal regions cannot differentiate semantic representations from baseline unconscious activity, which leads to failures in faithful retrieval (preferentially idiosyncratic lexical-semantic links, e.g., proper names), verbal fluency anomalies, semantic interference, dampened N400 effects, and various semiological deviances.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doença de Alzheimer
/
Disfunção Cognitiva
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Neuropsychologia
Ano de publicação:
2022
Tipo de documento:
Article