Come on mtDNA, light my fire.

Lawrence, Grace M E P; Holley, Caroline L; Schroder, Kate

Lawrence, Grace M E P; Holley, Caroline L; Schroder, Kate.

Afiliação

Lawrence GMEP; Institute for Molecular Bioscience and IMB Centre for Inflammation and Disease Research, The University of Queensland, St Lucia, QLD, Australia.
Holley CL; Institute for Molecular Bioscience and IMB Centre for Inflammation and Disease Research, The University of Queensland, St Lucia, QLD, Australia.
Schroder K; Institute for Molecular Bioscience and IMB Centre for Inflammation and Disease Research, The University of Queensland, St Lucia, QLD, Australia. Electronic address: k.schroder@imb.uq.edu.au.

Immunity ; 55(8): 1331-1333, 2022 08 09.

Article em En | MEDLINE | ID: mdl-35947975

ABSTRACT

ABSTRACT

Oxidized mitochondrial DNA (ox-mtDNA) activates NLRP3 inflammasome signaling through an ill-defined mechanism. In this issue of Immunity, Xian et al. reveal FEN1 endonuclease cleaves ox-mtDNA into fragments that escape mitochondria, igniting NLRP3 and cGAS-STING signaling and inflammation.

Assuntos

DNA Mitocondrial; Proteína 3 que Contém Domínio de Pirina da Família NLR; DNA Mitocondrial/genética; Inflamassomos; Mitocôndrias/genética; Transdução de Sinais

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: DNA Mitocondrial / Proteína 3 que Contém Domínio de Pirina da Família NLR Idioma: En Revista: Immunity Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Austrália

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