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Restriction of SARS-CoV-2 replication in the human placenta.
Takada, Kazuhide; Shimodai-Yamada, Sayaka; Suzuki, Mayumi; Trinh, Quang Duy; Takano, Chika; Kawakami, Kaori; Asai-Sato, Mikiko; Komatsu, Atsushi; Okahashi, Aya; Nagano, Nobuhiko; Misawa, Toshiya; Yamaguchi, Kyohei; Suzuki, Tadaki; Kawana, Kei; Morioka, Ichiro; Yamada, Hideto; Hayakawa, Satoshi; Hao, Hiroyuki; Komine-Aizawa, Shihoko.
Afiliação
  • Takada K; Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Japan.
  • Shimodai-Yamada S; Division of Human Pathology, Department of Pathology and Microbiology Nihon University School of Medicine, Japan.
  • Suzuki M; Division of Human Pathology, Department of Pathology and Microbiology Nihon University School of Medicine, Japan.
  • Trinh QD; Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Japan.
  • Takano C; Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Japan.
  • Kawakami K; Department of Obstetrics and Gynecology, Nihon University School of Medicine, Japan.
  • Asai-Sato M; Department of Obstetrics and Gynecology, Nihon University School of Medicine, Japan.
  • Komatsu A; Department of Obstetrics and Gynecology, Nihon University School of Medicine, Japan.
  • Okahashi A; Department of Pediatrics and Child Health, Nihon University School of Medicine, Japan.
  • Nagano N; Department of Pediatrics and Child Health, Nihon University School of Medicine, Japan.
  • Misawa T; Department of Obstetrics and Gynecology, Nagoya Ekisaikai Hospital, Japan.
  • Yamaguchi K; Department of Obstetrics and Gynecology, National Hospital Organization, Mie Chuo Medical Center, Japan.
  • Suzuki T; Department of Pathology, National Institute of Infectious Diseases, Japan.
  • Kawana K; Department of Obstetrics and Gynecology, Nihon University School of Medicine, Japan.
  • Morioka I; Department of Pediatrics and Child Health, Nihon University School of Medicine, Japan.
  • Yamada H; Center for Recurrent Pregnancy Loss, Teine Keijinkai Hospital Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan.
  • Hayakawa S; Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Japan.
  • Hao H; Division of Human Pathology, Department of Pathology and Microbiology Nihon University School of Medicine, Japan. Electronic address: hao.hiroyuki@nihon-u.ac.jp.
  • Komine-Aizawa S; Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Japan. Electronic address: aizawa.shihoko@nihon-u.ac.jp.
Placenta ; 127: 73-76, 2022 09.
Article em En | MEDLINE | ID: mdl-35973367
ABSTRACT
Although SARS-CoV-2 can infect human placental tissue, vertical transmission is rare. Therefore, the placenta may function as a barrier to inhibit viral transmission to the foetus, though the mechanisms remain unclear. In this study, we confirmed the presence of the SARS-CoV-2 genome in human placental tissue by in situ hybridization with antisense probes targeting the spike protein; tissue staining was much lower when using sense probes for the spike protein. To the best of our knowledge, this is the first evidence directly indicating inefficient viral replication in the SARS-CoV-2-infected placenta. Additional studies are required to reveal the detailed mechanisms.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Complicações Infecciosas na Gravidez / COVID-19 Limite: Female / Humans / Pregnancy Idioma: En Revista: Placenta Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Japão
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Complicações Infecciosas na Gravidez / COVID-19 Limite: Female / Humans / Pregnancy Idioma: En Revista: Placenta Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Japão