Functionalisation of ethereal-based saturated heterocycles with concomitant aerobic C-H activation and C-C bond formation.
Chem Sci
; 13(29): 8626-8633, 2022 Jul 29.
Article
em En
| MEDLINE
| ID: mdl-35974756
ABSTRACT
With an ever-growing emphasis on sustainable synthesis, aerobic C-H activation (the use of oxygen in air to activate C-H bonds) represents a highly attractive conduit for the development of novel synthetic methodologies. Herein, we report the air mediated functionalisation of various saturated heterocycles and ethers via aerobically generated radical intermediates to form new C-C bonds using acetylenic and vinyl triflones as radical acceptors. This enables access to a variety of acetylenic and vinyl substituted saturated heterocycles that are rich in synthetic value. Mechanistic studies and control reactions support an aerobic radical-based C-H activation mechanism.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Chem Sci
Ano de publicação:
2022
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Article