Amidosquaramides - a new anion binding motif with pH sensitive anion transport properties.
Org Biomol Chem
; 20(35): 7056-7066, 2022 09 14.
Article
em En
| MEDLINE
| ID: mdl-35993191
ABSTRACT
Stimuli responsive anion transport is becoming an important aspect of supramolecular anion recognition chemistry. Herein, we report the synthesis of a family of anion receptors that incorporate a new anion binding motif, amidosquaramides. We show using experimental and computational methods that these receptors have pKa values close to physiological pH but also display intramolecular H-bonding interactions that affect anion recognition. Moreover, moderate activity in a Cl-/NO3- exchange assay is observed at physiological pH that can be effectively 'switched on' when repeated under acidic conditions. The reported findings provide synthetic methods that can be used for the construction of more complex squaramide based anion receptors and also provide insight into the importance of conformational analysis when considering receptor design.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Transporte
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Revista:
Org Biomol Chem
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Irlanda