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The APP intracellular domain promotes LRRK2 expression to enable feed-forward neurodegenerative mechanisms in Parkinson's disease.
Zhang, Zhi-Wei; Tu, Haitao; Jiang, Mei; Vanan, Sarivin; Chia, Sook Yoong; Jang, Se-Eun; Saw, Wuan-Ting; Ong, Zhi-Wei; Ma, Dong-Rui; Zhou, Zhi-Dong; Xu, Jie; Guo, Kai-Hua; Yu, Wei-Ping; Ling, Shuo-Chien; Margolin, Richard A; Chain, Daniel G; Zeng, Li; Tan, Eng-King.
Afiliação
  • Zhang ZW; Neural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore 308433, Singapore.
  • Tu H; Neural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore 308433, Singapore.
  • Jiang M; Neural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore 308433, Singapore.
  • Vanan S; Department of Anatomy and Neurobiology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China.
  • Chia SY; Neural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore 308433, Singapore.
  • Jang SE; Neural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore 308433, Singapore.
  • Saw WT; Neural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore 308433, Singapore.
  • Ong ZW; Research Department, National Neuroscience Institute, Singapore General Hospital (SGH) Campus, Singapore 169856, Singapore.
  • Ma DR; Neural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore 308433, Singapore.
  • Zhou ZD; Department of Neurology, Singapore General Hospital, Singapore 169609, Singapore.
  • Xu J; Research Department, National Neuroscience Institute, Singapore General Hospital (SGH) Campus, Singapore 169856, Singapore.
  • Guo KH; Neuroscience and Behavioral Disorders Program, DUKE-NUS Graduate Medical School, Singapore 169857, Singapore.
  • Yu WP; Department of Anatomy and Neurobiology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China.
  • Ling SC; Department of Anatomy and Neurobiology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China.
  • Margolin RA; Animal Gene Editing Laboratory, Biological Resource Center, A*STAR, Singapore 138673, Singapore.
  • Chain DG; Institute of Molecular and Cell Biology, A*STAR, Singapore 138673, Singapore.
  • Zeng L; Neuroscience and Behavioral Disorders Program, DUKE-NUS Graduate Medical School, Singapore 169857, Singapore.
  • Tan EK; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore.
Sci Signal ; 15(748): eabk3411, 2022 08 23.
Article em En | MEDLINE | ID: mdl-35998231
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Sci Signal Assunto da revista: CIENCIA / FISIOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Singapura
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Sci Signal Assunto da revista: CIENCIA / FISIOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Singapura