Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes.

Akbari, Parsa; Sosina, Olukayode A; Bovijn, Jonas; Landheer, Karl; Nielsen, Jonas B; Kim, Minhee; Aykul, Senem; De, Tanima; Haas, Mary E; Hindy, George; Lin, Nan; Dinsmore, Ian R; Luo, Jonathan Z; Hectors, Stefanie; Geraghty, Benjamin; Germino, Mary; Panagis, Lampros; Parasoglou, Prodromos; Walls, Johnathon R; Halasz, Gabor; Atwal, Gurinder S; Jones, Marcus; LeBlanc, Michelle G; Still, Christopher D; Carey, David J; Giontella, Alice; Orho-Melander, Marju; Berumen, Jaime; Kuri-Morales, Pablo; Alegre-Díaz, Jesus; Torres, Jason M; Emberson, Jonathan R; Collins, Rory; Rader, Daniel J; Zambrowicz, Brian; Murphy, Andrew J; Balasubramanian, Suganthi; Overton, John D; Reid, Jeffrey G; Shuldiner, Alan R; Cantor, Michael; Abecasis, Goncalo R; Ferreira, Manuel A R; Sleeman, Mark W; Gusarova, Viktoria; Altarejos, Judith; Harris, Charles; Economides, Aris N; Idone, Vincent; Karalis, Katia

Akbari, Parsa; Sosina, Olukayode A; Bovijn, Jonas; Landheer, Karl; Nielsen, Jonas B; Kim, Minhee; Aykul, Senem; De, Tanima; Haas, Mary E; Hindy, George; Lin, Nan; Dinsmore, Ian R; Luo, Jonathan Z; Hectors, Stefanie; Geraghty, Benjamin; Germino, Mary; Panagis, Lampros; Parasoglou, Prodromos; Walls, Johnathon R; Halasz, Gabor; Atwal, Gurinder S; Jones, Marcus; LeBlanc, Michelle G; Still, Christopher D; Carey, David J; Giontella, Alice; Orho-Melander, Marju; Berumen, Jaime; Kuri-Morales, Pablo; Alegre-Díaz, Jesus; Torres, Jason M; Emberson, Jonathan R; Collins, Rory; Rader, Daniel J; Zambrowicz, Brian; Murphy, Andrew J; Balasubramanian, Suganthi; Overton, John D; Reid, Jeffrey G; Shuldiner, Alan R; Cantor, Michael; Abecasis, Goncalo R; Ferreira, Manuel A R; Sleeman, Mark W; Gusarova, Viktoria; Altarejos, Judith; Harris, Charles; Economides, Aris N; Idone, Vincent; Karalis, Katia.

Afiliação

Akbari P; Regeneron Genetics Center, Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Sosina OA; Regeneron Genetics Center, Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Bovijn J; Regeneron Genetics Center, Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Landheer K; Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Nielsen JB; Regeneron Genetics Center, Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Kim M; Regeneron Genetics Center, Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Aykul S; Regeneron Genetics Center, Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
De T; Regeneron Genetics Center, Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Haas ME; Regeneron Genetics Center, Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Hindy G; Regeneron Genetics Center, Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Lin N; Regeneron Genetics Center, Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Dinsmore IR; Department of Molecular and Functional Genomics, Geisinger Health System, Danville, PA, USA.
Luo JZ; Department of Molecular and Functional Genomics, Geisinger Health System, Danville, PA, USA.
Hectors S; Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Geraghty B; Regeneron Genetics Center, Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Germino M; Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Panagis L; Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Parasoglou P; Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Walls JR; Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Halasz G; Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Atwal GS; Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Jones M; Regeneron Genetics Center, Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
LeBlanc MG; Regeneron Genetics Center, Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Still CD; Geisinger Obesity Institute, Geisinger Health System, Danville, PA, USA.
Carey DJ; Geisinger Obesity Institute, Geisinger Health System, Danville, PA, USA.
Giontella A; Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
Orho-Melander M; Department of Medicine, University of Verona, Verona, Italy.
Berumen J; Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
Kuri-Morales P; Unidad de Medicina Experimental de la Facultad de Medicina de la Universidad Nacional Autónoma de México, Mexico City, Mexico.
Alegre-Díaz J; Unidad de Medicina Experimental de la Facultad de Medicina de la Universidad Nacional Autónoma de México, Mexico City, Mexico.
Torres JM; Instituto Tecnológico y de Estudios Superiores de Monterrey, Monterrey, Mexico.
Emberson JR; Unidad de Medicina Experimental de la Facultad de Medicina de la Universidad Nacional Autónoma de México, Mexico City, Mexico.
Collins R; MRC Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Rader DJ; Clinical Trial Service Unit & Epidemiological Studies Unit Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Zambrowicz B; MRC Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Murphy AJ; Clinical Trial Service Unit & Epidemiological Studies Unit Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Balasubramanian S; Clinical Trial Service Unit & Epidemiological Studies Unit Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Overton JD; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Reid JG; Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Shuldiner AR; Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Cantor M; Regeneron Genetics Center, Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Abecasis GR; Regeneron Genetics Center, Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Ferreira MAR; Regeneron Genetics Center, Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Sleeman MW; Regeneron Genetics Center, Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Gusarova V; Regeneron Genetics Center, Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Altarejos J; Regeneron Genetics Center, Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Harris C; Regeneron Genetics Center, Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Economides AN; Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Idone V; Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Karalis K; Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.

Nat Commun ; 13(1): 4844, 2022 08 23.

Article em En | MEDLINE | ID: mdl-35999217

Assuntos

Diabetes Mellitus Tipo 2; Subunidades beta de Inibinas/genética; Tecido Adiposo; Adiposidade/genética; Diabetes Mellitus Tipo 2/genética; Exoma/genética; Humanos; Mutação

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Subunidades beta de Inibinas / Diabetes Mellitus Tipo 2 Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

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