How reliably can algorithms identify eosinophilic asthma phenotypes using non-invasive biomarkers?
Clin Transl Allergy
; 12(8): e12182, 2022 Aug.
Article
em En
| MEDLINE
| ID: mdl-36000018
ABSTRACT
Background and Aims:
Asthma is a heterogeneous respiratory disease that encompasses different inflammatory and functional endophenotypes. Many non-invasive biomarkers has been investigated to its pathobiology. Heany et al proposed a clinical algorithm that classifies severe asthmatic patients into likely-eosinophilic phenotypes, based on accessible biomarkers PBE, current treatment, FeNO, presence of nasal polyps (NP) and age of onset. Materials andMethods:
We assessed the concordance between the algorithm proposed by Heany et al. with sputum examination, the gold standard, in 145 asthmatic patients of the MEGA cohort with varying grades of severity.Results:
No correlation was found between both classifications 0.025 (CI = 0.013-0.037). Moreover, no relationship was found between sputum eosinophilia and peripheral blood eosinophilia count in the total studied population. Discussion andConclusion:
In conclusion, our results suggest that grouping the biomarkers proposed by Heany et al. are insufficient to diagnose eosinophilic phenotypes in asthmatic patients. Sputum analysis remains the gold standard to assess airway inflammation.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Clin Transl Allergy
Ano de publicação:
2022
Tipo de documento:
Article