Novel Isoxazole Derivative Attenuates Ethanol-Induced Gastric Mucosal Injury through Inhibition of H<sup>+</sup>/K<sup>+</sup>-ATPase Pump, Oxidative Stress and Inflammatory Pathways.

Razzaq, Sidra; Minhas, Amber Mahmood; Qazi, Neelum Gul; Nadeem, Humaira; Khan, Arif-Ullah; Ali, Fawad; Hassan, Syed Shams Ul; Bungau, Simona

Novel Isoxazole Derivative Attenuates Ethanol-Induced Gastric Mucosal Injury through Inhibition of H⁺/K⁺-ATPase Pump, Oxidative Stress and Inflammatory Pathways.

Razzaq, Sidra; Minhas, Amber Mahmood; Qazi, Neelum Gul; Nadeem, Humaira; Khan, Arif-Ullah; Ali, Fawad; Hassan, Syed Shams Ul; Bungau, Simona.

Afiliação

Razzaq S; Department of Pharmacology, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad 46000, Pakistan.
Minhas AM; Department of Pharmacology, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad 46000, Pakistan.
Qazi NG; Department of Pharmacology, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad 46000, Pakistan.
Nadeem H; Department of Pharmacology, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad 46000, Pakistan.
Khan AU; Department of Pharmacology, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad 46000, Pakistan.
Ali F; Department of Pharmacy, Kohat University of Science and Technology, Kohat 26000, Pakistan.
Hassan SSU; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.
Bungau S; Department of Natural Product Chemistry, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.

Molecules ; 27(16)2022 Aug 09.

Article em En | MEDLINE | ID: mdl-36014311

Assuntos

Antiulcerosos; Helicobacter pylori; Úlcera Gástrica; Animais; Antiulcerosos/química; Antioxidantes/metabolismo; Etanol/metabolismo; Mucosa Gástrica; Glutationa/metabolismo; ATPase Trocadora de Hidrogênio-Potássio/metabolismo; Isoxazóis/farmacologia; Estresse Oxidativo; Extratos Vegetais/química; Proteômica; Ratos; Úlcera Gástrica/induzido quimicamente; Úlcera Gástrica/tratamento farmacológico; Úlcera Gástrica/prevenção & controle

Palavras-chave

H+/K+-ATPase inhibition; anti-inflammatory; antioxidant; gastric ulcer; in-silico; isoxazole

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Úlcera Gástrica / Helicobacter pylori / Antiulcerosos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Paquistão

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