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Shear wave elastography: How well does it perform in chronic hepatitis D virus infection?
Yang, Alexander H; Yardeni, David; Hercun, Julian; Kleiner, David E; Ling, Alexander; Marko, Jamie; Heller, Theo; Koh, Christopher.
Afiliação
  • Yang AH; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
  • Yardeni D; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
  • Hercun J; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
  • Kleiner DE; Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
  • Ling A; Department of Radiology, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
  • Marko J; Department of Radiology, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
  • Heller T; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
  • Koh C; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
J Viral Hepat ; 29(12): 1127-1133, 2022 12.
Article em En | MEDLINE | ID: mdl-36062402
ABSTRACT
Hepatitis delta virus (HDV) infection is associated with accelerated progression of liver disease to cirrhosis. Shear wave elastography (SWE) is a non-invasive evaluation method of liver fibrosis. Its performance in accurately characterizing HDV fibrosis compared to other noninvasive markers remains unknown. We assessed the performance of SWE in patients with chronic HDV, Hepatitis B (HBV) and Hepatitis C (HCV) infection. Cirrhosis was determined by histology or clinical data. Area under receiver operator characteristics (AUROC) was used to assess diagnostic performance in identifying cirrhosis by SWE in comparison with Fibroscan® (VCTE) and serologic tests of fibrosis. 158 patients with chronic hepatitis (HDV44%, HBV 46% and HCV 29%) were evaluated. Cirrhosis was diagnosed in 28 (17.7%) patients. Mean noninvasive fibrosis measurements for the HBV/HCV and HDV groups, respectively, were as follows APRI 0.73 ± 1.08 and 1.3 ± 1.38; FIB-4 1.90 ± 2.24 and 2.33 ± 2.24; VCTE 8.9 ± 6.7 kPa vs 10.4 ± 5.3 kPa; SWE 1.5 ± 0.2 m/s and 1.6 ± 0.2 m/s. The performance of SWE in detecting HDV-induced cirrhosis (AUROC 0.84, 95% CI 0.71-0.97) was slightly lower than in HBV/HCV induced disease (AUROC 0.88, 95% CI 0.81-0.96). For HDV patients, the performance of SWE was comparable to VCTE and slightly better than APRI and FIB-4 especially in APRI and FIB-4 indeterminate zones. The overall less accurate performance of noninvasive markers in HDV in comparison with HBV and HCV may be a result of significant hepatic inflammation in HDV.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hepatite C / Hepatite D Crônica / Técnicas de Imagem por Elasticidade Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Revista: J Viral Hepat Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hepatite C / Hepatite D Crônica / Técnicas de Imagem por Elasticidade Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Revista: J Viral Hepat Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos