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Otopathologic and Computed Tomography Correlation of Internal Auditory Canal Diverticula in Otosclerosis.
Wells, Dawson; Knoll, Renata M; Kozin, Elliott; Chen, Jenny X; Reinshagen, Katherine L; Staecker, Hinrich; Curtin, Hugh D; McKenna, Michael J; Nadol, Joseph B; Quesnel, Alicia M.
Afiliação
  • Reinshagen KL; Department of Radiology, Massachusetts Eye and Ear, Boston, Massachusetts.
  • Staecker H; Department of Otolaryngology-Head and Neck Surgery, University of Kansas School of Medicine, Kansas City, Kansas.
  • Curtin HD; Department of Radiology, Massachusetts Eye and Ear, Boston, Massachusetts.
  • McKenna MJ; Akouos Inc., Boston, Massachusetts.
Otol Neurotol ; 43(9): e957-e962, 2022 10 01.
Article em En | MEDLINE | ID: mdl-36075107
ABSTRACT

INTRODUCTION:

Internal auditory canal (IAC) diverticula, also known as IAC cavitary lesions or anterior cupping of the IAC, observed in otopathologic specimens and high-resolution computed tomography (CT) scans of the temporal bone are thought to be related to otosclerosis. Herein, we examined the usefulness of CT scans in identifying diverticula and determined whether IAC diverticula are associated with otosclerosis on otopathology.

METHODS:

One hundred five consecutive specimens were identified from the National Temporal Bone Hearing and Balance Pathology Resource Registry. Inclusion criteria included the availability of histologic slides and postmortem specimen CT scans. Exclusion criteria included cases with severe postmortem changes or lesions causing bony destruction of the IAC.

RESULTS:

Ninety-seven specimens met criteria for study. Of these, 42% of the specimens were from male patients, and the average age of death was 77 years (SD = 18 yr). IAC diverticula were found in 48 specimens, of which 46% were identified in the CT scans. The mean area of the IAC diverticula was 0.34 mm 2 . The sensitivity and specificity of detecting IAC diverticula based on CT were 77% and 63%, respectively. Overall, 27% of specimens had otosclerosis. Histologic IAC diverticula were more common in specimens with otosclerosis than those without (37.5% versus 16%; p = 0.019). Cases with otosclerosis had a greater mean histologic diverticula area compared with nonotosclerosis cases (0.69 mm 2 versus 0.14 mm 2 ; p = 0.001).

CONCLUSION:

IAC diverticula are commonly found in otopathologic specimens with varied etiologies, but larger diverticula are more likely to be associated with otosclerosis. The sensitivity and specificity of CT scans to detect IAC diverticula are limited.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Otosclerose / Divertículo / Orelha Interna Tipo de estudo: Prognostic_studies Limite: Aged / Humans / Male Idioma: En Revista: Otol Neurotol Assunto da revista: NEUROLOGIA / OTORRINOLARINGOLOGIA Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Otosclerose / Divertículo / Orelha Interna Tipo de estudo: Prognostic_studies Limite: Aged / Humans / Male Idioma: En Revista: Otol Neurotol Assunto da revista: NEUROLOGIA / OTORRINOLARINGOLOGIA Ano de publicação: 2022 Tipo de documento: Article