Acetaminophen-induced reduction of NIMA-related kinase 7 expression exacerbates acute liver injury.
JHEP Rep
; 4(10): 100545, 2022 Oct.
Article
em En
| MEDLINE
| ID: mdl-36097583
ALF, acute liver failure; ALI, acute liver injury; ALT, alanine aminotransferase; APAP, acetaminophen; AST, aspartate aminotransferase; Apoptosis; CCK-8, cell counting kit 8; CYP2E1; Ctrl, control; GSH, glutathione; Het, heterozygous; LDH, lactate dehydrogenase; MCP-1, monocyte chemoattractant protein-1; MDA, malondialdehyde; NAPQI, N-acetyl-p-benzoquinone imine; ND1, NADH dehydrogenase 1; NEK7, NIMA-related kinase 7; NLRP3; PI, propidium iodide; ROS, reactive oxygen species; TNF-α, tumour necrosis factor-alpha; TPM, transcripts per kilobase of exon model per million mapped reads; WT, wild-type; cKO mice, conditional knockout mice; iKO mice, inducible knockout mice; si, small interfering
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1
Base de dados:
MEDLINE
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
JHEP Rep
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China