Electrogenerated base-promoted cyclopropanation using alkyl 2-chloroacetates.
Beilstein J Org Chem
; 18: 1116-1122, 2022.
Article
em En
| MEDLINE
| ID: mdl-36105721
ABSTRACT
The electrochemical reduction conditions of the reaction of alkyl 2-chloroacetates in Bu4NBr/DMF using a divided cell equipped with Pt electrodes to produce the corresponding cyclopropane derivatives in moderate yields were discovered. The reaction conditions were optimized, the scope and limitations, as well as scale-up reactions were investigated. The presented method for the electrochemical production of cyclopropane derivatives is an environmentally friendly and easy to perform synthetic procedure.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Beilstein J Org Chem
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Japão