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Electrogenerated base-promoted cyclopropanation using alkyl 2-chloroacetates.
Matsumoto, Kouichi; Hayashi, Yuta; Hamasaki, Kengo; Matsuse, Mizuki; Suzuki, Hiyono; Nishiwaki, Keiji; Kawashita, Norihito.
Afiliação
  • Matsumoto K; Department of Chemistry, School of Science and Engineering, Kindai University 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan.
  • Hayashi Y; Department of Chemistry, School of Science and Engineering, Kindai University 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan.
  • Hamasaki K; Department of Chemistry, School of Science and Engineering, Kindai University 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan.
  • Matsuse M; Department of Chemistry, School of Science and Engineering, Kindai University 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan.
  • Suzuki H; Department of Chemistry, School of Science and Engineering, Kindai University 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan.
  • Nishiwaki K; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Kindai University 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan.
  • Kawashita N; Department of Life Science, School of Science and Engineering, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan.
Beilstein J Org Chem ; 18: 1116-1122, 2022.
Article em En | MEDLINE | ID: mdl-36105721
ABSTRACT
The electrochemical reduction conditions of the reaction of alkyl 2-chloroacetates in Bu4NBr/DMF using a divided cell equipped with Pt electrodes to produce the corresponding cyclopropane derivatives in moderate yields were discovered. The reaction conditions were optimized, the scope and limitations, as well as scale-up reactions were investigated. The presented method for the electrochemical production of cyclopropane derivatives is an environmentally friendly and easy to perform synthetic procedure.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Beilstein J Org Chem Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Japão
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Beilstein J Org Chem Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Japão