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Immune tolerance against infused FVIII in hemophilia A is mediated by PD-L1+ Tregs.
Becker-Gotot, Janine; Meissner, Mirjam; Kotov, Vadim; Jurado-Mestre, Blanca; Maione, Andrea; Pannek, Andreas; Albert, Thilo; Flores, Chrystel; Schildberg, Frank A; Gleeson, Paul A; Reipert, Birgit M; Oldenburg, Johannes; Kurts, Christian.
Afiliação
  • Becker-Gotot J; Institute of Molecular Medicine and Experimental Immunology (IMMEI), Rheinische Friedrich-Wilhelms-Universität, Venusberg Campus 1, Bonn, Germany.
  • Meissner M; Institute of Molecular Medicine and Experimental Immunology (IMMEI), Rheinische Friedrich-Wilhelms-Universität, Venusberg Campus 1, Bonn, Germany.
  • Kotov V; Institute of Molecular Medicine and Experimental Immunology (IMMEI), Rheinische Friedrich-Wilhelms-Universität, Venusberg Campus 1, Bonn, Germany.
  • Jurado-Mestre B; Institute of Molecular Medicine and Experimental Immunology (IMMEI), Rheinische Friedrich-Wilhelms-Universität, Venusberg Campus 1, Bonn, Germany.
  • Maione A; Institute of Molecular Medicine and Experimental Immunology (IMMEI), Rheinische Friedrich-Wilhelms-Universität, Venusberg Campus 1, Bonn, Germany.
  • Pannek A; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria, Australia.
  • Albert T; Institute of Molecular Medicine and Experimental Immunology (IMMEI), Rheinische Friedrich-Wilhelms-Universität, Venusberg Campus 1, Bonn, Germany.
  • Flores C; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria, Australia.
  • Schildberg FA; Institute for Experimental Hematology and Transfusion Medicine (IHT), Rheinische Friedrich-Wilhelms-Universität, Venusberg Campus 1, Bonn, Germany.
  • Gleeson PA; Institute of Molecular Medicine and Experimental Immunology (IMMEI), Rheinische Friedrich-Wilhelms-Universität, Venusberg Campus 1, Bonn, Germany.
  • Reipert BM; Clinic for Orthopedics and Trauma Surgery, University Hospital Bonn, Bonn, Germany.
  • Oldenburg J; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria, Australia.
  • Kurts C; IMC University of Applied Sciences Krems, Krems, Austria.
J Clin Invest ; 132(22)2022 11 15.
Article em En | MEDLINE | ID: mdl-36107620
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator VIII / Linfócitos B / Linfócitos T Reguladores / Antígeno B7-H1 / Hemofilia A / Tolerância Imunológica / Isoanticorpos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Clin Invest Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator VIII / Linfócitos B / Linfócitos T Reguladores / Antígeno B7-H1 / Hemofilia A / Tolerância Imunológica / Isoanticorpos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Clin Invest Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Alemanha