Thrombospondin 1 and Nuclear Factor Kappa B Signaling Pathways in Non-alcoholic Fatty Liver Disease.
J Gastrointestin Liver Dis
; 31(3): 309-316, 2022 09 15.
Article
em En
| MEDLINE
| ID: mdl-36112712
ABSTRACT
AIM:
We aimed to evaluate the circulating thrombospondin-1 (TSP-1) and nuclear factor kappa B (NF-κB) in nonalcoholic fatty liver disease (NAFLD) in order to integrate these signaling pathways in the inflammatory and fibrogenic processes of this liver disorder.METHODS:
Ninety-five NAFLD patients were recruited in the study. The study also included 83 age-sex matched healthy controls.RESULTS:
The number of patients with metabolic syndrome (MetS) criteria was 57 (60%). TSP-1 level was found to be statistically significantly lower in the NAFLD group compared to the control group (p=0.037). However, NF-κB level was found to be significantly higher in the NAFLD group compared to the control group (p=0.004). There was a significant negative correlation between plasma TSP-1 levels with glucose (r=-0.235, p=0.022), alanine aminotransferase (r=-0.261, p=0.011) and aspartate transaminase (r=-0.328, p=0.001) levels. In addition, a significant negative correlation was found between plasma TSP-1 and NF-κB levels (r=-0.729, p<0.001).CONCLUSIONS:
Our results suggest a close relationship between increased NF-κB and reduced TSP-1 in NAFLD. TSP-1 and NF-κB signaling pathways might have a role in the inflammatory and fibrogenic processes. Furthermore, they may be used as a noninvasive marker and could assist as a therapeutic target for NAFLD.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
NF-kappa B
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Trombospondina 1
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Hepatopatia Gordurosa não Alcoólica
Limite:
Humans
Idioma:
En
Revista:
J Gastrointestin Liver Dis
Assunto da revista:
GASTROENTEROLOGIA
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Turquia