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Risk factors associated with abandonment of care in retinoblastoma: analysis of 692 patients from 10 countries.
Nishath, Thamanna; Li, Xiudi; Chandramohan, Arthika; Othus, Megan; Ji, Xunda; Zou, Yihua; Sultana, Sadia; Rashid, Riffat; Sherief, Sadik Taju; Cassoux, Nathalie; Garcia Leon, Juan Luis; Díaz Coronado, Rosdali; López, Arturo Manuel Zapata; Ushakova, Tatiana L; Polyakov, Vladimir G; Roy, Soma Rani; Ahmad, Alia; Reddy, Ashwin; Sagoo, Mandeep S; Al Harby, Lamis; Kim, Jonathan W; Berry, Jesse L; Polski, Ashley; Astbury, Nick; Bascaran, Cova; Blum, Sharon; Bowman, Richard; Burton, Matthew J; Foster, Allen; Gomel, Nir; Keren-Froim, Naama; Madgar, Shiran; Zondervan, Marcia; Kaliki, Swathi; Fabian, Ido Didi; Stacey, Andrew.
Afiliação
  • Nishath T; Department of Ophthalmology, University of Washington, Seattle, Washington, USA tnishath@uw.edu.
  • Li X; Department of Biostatistics, University of Washington, Seattle, Washington, USA.
  • Chandramohan A; Division of Ophthalmology, Seattle Children's Hospital, Seattle, Washington, USA.
  • Othus M; Department of Biostatistics, University of Washington, Seattle, Washington, USA.
  • Ji X; Department of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Yang Pu Qu, Shanghai, China.
  • Zou Y; Department of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Yang Pu Qu, Shanghai, China.
  • Sultana S; Department of Oculoplasty and Ocular Oncology, Ispahani Islamia Eye Institute and Hospital, Dhaka, Bangladesh.
  • Rashid R; Department of Oculoplasty and Ocular Oncology, Ispahani Islamia Eye Institute and Hospital, Dhaka, Bangladesh.
  • Sherief ST; Department of Ophthalmology, Addis Ababa University, Addis Ababa, Ethiopia.
  • Cassoux N; Department of Ophthalmology, Institut Curie, Universite de Paris UFR de Medecine de Paris Centre, Paris, France.
  • Garcia Leon JL; Anglo-American Clinic, Lima, Peru.
  • Díaz Coronado R; Instituto Nacional de Enfermedades Neoplasicas, Lima, Peru.
  • López AMZ; Instituto Nacional de Enfermedades Neoplasicas, Lima, Peru.
  • Ushakova TL; Head and Neck Tumors, SRI of Pediatric Oncology and Hematology of NN Blokhin National Medical Research Center Oncology of Russian Federation, Moscow, Russian Federation.
  • Polyakov VG; Pediatric Oncology, Medical Academy of Postgraduate Education, Moscow, Russian Federation.
  • Roy SR; Head and Neck Tumors Department, SRI of Pediatric Oncology and Hematology of NN Blokhin National Medical Research Center Oncology of Russian Federation, Moscow, Russian Federation.
  • Ahmad A; Russian Medical Academy of Postgraduate Education, Moscow, Russian Federation.
  • Reddy A; Chittagong Eye Infirmary and Training Complex, Chittagong, Bangladesh.
  • Sagoo MS; The Children's Hospital and the Institute of Child Health, Lahore, Pakistan.
  • Al Harby L; Ophthalmology, Barts Health NHS Trust, London, UK.
  • Kim JW; Paediatric Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust, London, UK.
  • Berry JL; Ophthalmology, Barts Health NHS Trust, London, UK.
  • Polski A; NIHR Biomedical Research Centre for Ophthalmology, Joint Library of Ophthalmology Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, UK.
  • Astbury N; Ocular Oncology, Moorfields Eye Hospital NHS Foundation Trust, London, UK.
  • Bascaran C; Barts Health NHS Trust, The Royal London Hospital, London, UK.
  • Blum S; USC Roski Eye Institute, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
  • Bowman R; The Vision Center, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
  • Burton MJ; USC Roski Eye Institute, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
  • Foster A; The Vision Center, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
  • Gomel N; USC Roski Eye Institute, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
  • Keren-Froim N; The Vision Center, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
  • Madgar S; International Centre for Eye Health, London School of Hygiene and Tropical Medicine, London, UK.
  • Zondervan M; International Centre for Eye Health, London School of Hygiene and Tropical Medicine, London, UK.
  • Kaliki S; The Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Israel.
  • Fabian ID; International Centre for Eye Health, London School of Hygiene and Tropical Medicine, London, UK.
  • Stacey A; The Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Israel.
Br J Ophthalmol ; 107(12): 1818-1822, 2023 11 22.
Article em En | MEDLINE | ID: mdl-36113955
ABSTRACT

BACKGROUND:

Rates of care abandonment for retinoblastoma (RB) demonstrate significant geographical variation; however, other variables that place a patient at risk of abandoning care remain unclear. This study aims to identify the risk factors for care abandonment across a multinational set of patients.

METHODS:

A prospective, observational study of 692 patients from 11 RB centres in 10 countries was conducted from 1 January 2019 to 31 December 2019. Multivariate logistic regression was used to identify risk factors associated with higher rates of care abandonment.

RESULTS:

Logistic regression showed a higher risk of abandoning care based on country (high-risk countries include Bangladesh (OR=18.1), Pakistan (OR=45.5) and Peru (OR=9.23), p<0.001), female sex (OR=2.39, p=0.013) and advanced clinical stage (OR=4.22, p<0.001). Enucleation as primary treatment was not associated with a higher risk of care abandonment (OR=0.59, p=0.206).

CONCLUSION:

Country, advanced disease and female sex were all associated with higher rates of abandonment. In this analysis, enucleation as the primary treatment was not associated with abandonment. Further research investigating cultural barriers can enable the building of targeted retention strategies unique to each country.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Retinoblastoma / Neoplasias da Retina Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans Idioma: En Revista: Br J Ophthalmol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Retinoblastoma / Neoplasias da Retina Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans Idioma: En Revista: Br J Ophthalmol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos