Histone deacetylase inhibitor panobinostat in combination with rapamycin confers enhanced efficacy against triple-negative breast cancer.

Wu, Kunlin; Zhang, Huihao; Zhou, Linlin; Chen, Ling; Mo, Caiqin; Xu, Sunwang; Lin, Junyu; Kong, Lingjun; Chen, Xiangjin

Wu, Kunlin; Zhang, Huihao; Zhou, Linlin; Chen, Ling; Mo, Caiqin; Xu, Sunwang; Lin, Junyu; Kong, Lingjun; Chen, Xiangjin.

Afiliação

Wu K; Department of Thyroid and Breast Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, 350004, China. Electronic address: jerrywkl123@fjmu.edu.cn.
Zhang H; Department of Thyroid and Breast Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, 350004, China.
Zhou L; Institute of Immunotherapy, Fujian Medical University, Fuzhou, Fujian, 350122, China.
Chen L; Department of Thyroid and Breast Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, 350004, China.
Mo C; Department of Thyroid and Breast Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, 350004, China.
Xu S; Department of Thyroid and Breast Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, 350004, China.
Lin J; Department of Thyroid and Breast Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, 350004, China.
Kong L; Department of Thyroid and Breast Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, 350004, China.
Chen X; Department of Thyroid and Breast Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, 350004, China. Electronic address: rjbhcxj@fjmu.edu.cn.

Exp Cell Res ; 421(1): 113362, 2022 12 01.

Article em En | MEDLINE | ID: mdl-36152730

Assuntos

Inibidores de Histona Desacetilases; Neoplasias de Mama Triplo Negativas; Camundongos; Animais; Humanos; Panobinostat/farmacologia; Panobinostat/uso terapêutico; Inibidores de Histona Desacetilases/farmacologia; Neoplasias de Mama Triplo Negativas/tratamento farmacológico; Neoplasias de Mama Triplo Negativas/metabolismo; Caspase 3; Sirolimo/farmacologia; Camundongos Nus; Espécies Reativas de Oxigênio; Sincalida; Antígeno Ki-67; Linhagem Celular Tumoral; Ensaios Antitumorais Modelo de Xenoenxerto; Serina-Treonina Quinases TOR; Histona Desacetilases

Palavras-chave

Endoplasmic reticulum stress; Panobinostat; ROS; Rapamycin; Triple-negative breast cancer

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores de Histona Desacetilases / Neoplasias de Mama Triplo Negativas Limite: Animals / Humans Idioma: En Revista: Exp Cell Res Ano de publicação: 2022 Tipo de documento: Article

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