New Jatrophane-Type Diterpenoids from Euphorbia kansui as Potential MDR Reversal Agents.
Chem Biodivers
; 19(11): e202200660, 2022 Nov.
Article
em En
| MEDLINE
| ID: mdl-36156394
ABSTRACT
A serial jatrophane-type diterpenoids, comprised with three undescribed compounds kanesulones C-E (1-3) and four known ones (4-7), were obtained from the roots of Euphorbia kansui. The structures of compounds 1-3 were elucidated by detailed interpretation of their spectroscopic data, especially 2D-NMR and HR-ESI-MS, the absolute configuration of 1 was revealed by single crystal X-ray diffraction. These isolates were assayed for their multidrug resistance reversing activities on human breast adenocarcinoma cell line MCF-7/ADR. Compound 1 possessed potential as low toxic MDR modulator that could promote the efficacy of anticancer drug adriamycin ca. 85-fold at 5â
µM, as 12â
times stronger than the positive drug verapamil.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Euphorbia
/
Diterpenos
Limite:
Humans
Idioma:
En
Revista:
Chem Biodivers
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2022
Tipo de documento:
Article