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Regulatory Effects of Lycium barbarum Extract and Isolated Scopoletin on Atopic Dermatitis-Like Skin Inflammation.
Bak, Seon Gyeong; Lim, Hyung-Jin; Won, Yeong-Seon; Lee, Soyoung; Cheong, Sun Hee; Lee, Seong Jin; Bae, Eun Young; Lee, Seung Woong; Lee, Seung Jae; Rho, Mun-Chual.
Afiliação
  • Bak SG; Functional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup 56212, Republic of Korea.
  • Lim HJ; Functional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup 56212, Republic of Korea.
  • Won YS; Functional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup 56212, Republic of Korea.
  • Lee S; Functional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup 56212, Republic of Korea.
  • Cheong SH; Department of Marine Bio Food Science, Chonnam National University, Yeosu 59626, Republic of Korea.
  • Lee SJ; CHA MEDITECH Co., Ltd., 199 Techno 2-ro, Daejeon 34025, Republic of Korea.
  • Bae EY; Elohim Co., Ltd, R&D Center, 199 Techno 2-ro, Daejeon 34025, Republic of Korea.
  • Lee SW; Functional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup 56212, Republic of Korea.
  • Lee SJ; Functional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup 56212, Republic of Korea.
  • Rho MC; Functional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup 56212, Republic of Korea.
Biomed Res Int ; 2022: 2475699, 2022.
Article em En | MEDLINE | ID: mdl-36158872
Lycium barbarum and scopoletin are widely used in oriental Eastern medicine and are often consumed as teas. In this study, proinflammatory cytokines expressed in human keratinocytes (HaCaT) were induced by skin diseases caused by 2,4-dinitrochlorobenzene (DNCB) and tumor necrosis factor alpha (TNF-α)/interferon gamma (IFN-γ). The inhibitory activity of L. barbarum EtOH extract (LBE) and scopoletin on proinflammatory cytokines and chemokines was investigated. In the DNCB-induced animal model, oral administration of LBE inhibited skin lesions and proinflammatory cytokines and chemokines and showed inhibitory effects in vitro. Additionally, as a result of examining the efficacy of scopoletin isolated from L. barbarum, scopoletin in HaCaT cells showed inhibitory effects on proinflammatory cytokines and chemokines. It shows promise in the treatment of chronic skin diseases.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Lycium / Dermatite Atópica Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Biomed Res Int Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Lycium / Dermatite Atópica Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Biomed Res Int Ano de publicação: 2022 Tipo de documento: Article