The levels of oxidative stress in a combination of stress factors.
J Med Life
; 15(8): 927-931, 2022 Aug.
Article
em En
| MEDLINE
| ID: mdl-36188645
ABSTRACT
We studied the effect of the combined action of ionizing radiation and induced immobilization stress on the lipid peroxidation process and antioxidant protection of organs (mesenteric lymph nodes, spleen, adrenal glands, thymus, and liver) and immune cels - the blood lymphocytes. Results were obtained on the role of free-radical oxidation in combination with exposure to ionizing radiation and immobilization stress at an early stage in the experiment. Gamma radiation in the acute period resulted in significant changes in lipoperoxidation and antioxidant systems. The first period of immobilization stress was marked by the imbalance of LPO-AOS systems disturbance with an accumulation of toxic compounds in tissues which had affected their function. The combined sublethal gamma radiation and immobilization stress disturbed the functional activity of adaptive systems of the body in the early stage of adaptation syndrome. Furthermore, the results show the dominant role of ionizing radiation in it.
Palavras-chave
AOS antioxidant system; CT catalase; DCs diene conjugates; GPx glutathione peroxidase; GSR glutathione reductase; Gy gray; LPO lipid peroxidation; MDA malondialdehyde; NJSO non-commercial joint-stock organization; ROIs reactive oxygen intermediates; antioxidant protection; combined effects; free-radical processes; immobilization stress; radiation
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Estresse Oxidativo
/
Antioxidantes
Limite:
Humans
Idioma:
En
Revista:
J Med Life
Assunto da revista:
MEDICINA
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Cazaquistão