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Novel 1,3-diaryl pyrazole derivatives bearing methylsulfonyl moiety: Design, synthesis, molecular docking and dynamics, with dual activities as anti-inflammatory and anticancer agents through selectively targeting COX-2.
Shaker, Ahmed M M; Shahin, Mai I; AboulMagd, Asmaa M; Abdel Aleem, Seham A; Abdel-Rahman, Hamdy M; Abou El Ella, Dalal A.
Afiliação
  • Shaker AMM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Nahda University, Beni-Suef 62517, Egypt. Electronic address: ahmed.shaker@nub.edu.eg.
  • Shahin MI; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo 11566, Egypt.
  • AboulMagd AM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Nahda University, Beni-Suef 62517, Egypt.
  • Abdel Aleem SA; Department of Histology, Faculty of Medicine, Minia University, Minia 61519, Egypt.
  • Abdel-Rahman HM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Nahda University, Beni-Suef 62517, Egypt; Department of Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt. Electronic address: hamdym@aun.edu.eg.
  • Abou El Ella DA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo 11566, Egypt.
Bioorg Chem ; 129: 106143, 2022 Dec.
Article em En | MEDLINE | ID: mdl-36191430
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores de Ciclo-Oxigenase 2 / Antineoplásicos Limite: Humans Idioma: En Revista: Bioorg Chem Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores de Ciclo-Oxigenase 2 / Antineoplásicos Limite: Humans Idioma: En Revista: Bioorg Chem Ano de publicação: 2022 Tipo de documento: Article