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Associations of urinary orosomucoid, N-acetyl-ß-D-glucosaminidase, and albumin with blood pressure and hypertension after 7 years. The Tromsø Study.
Brobak, Karl M; Andreassen, Runa M; Melsom, Toralf; Høieggen, Aud; Norvik, Jon V; Solbu, Marit D.
Afiliação
  • Brobak KM; Section of Nephrology, University Hospital of North Norway, Tromsø, Norway.
  • Andreassen RM; Metabolic and Renal Research Group, UiT The Arctic University of Norway, Tromsø, Norway.
  • Melsom T; Metabolic and Renal Research Group, UiT The Arctic University of Norway, Tromsø, Norway.
  • Høieggen A; Helgeland Hospital Trust, Sandnessjøen, Norway.
  • Norvik JV; Section of Nephrology, University Hospital of North Norway, Tromsø, Norway.
  • Solbu MD; Metabolic and Renal Research Group, UiT The Arctic University of Norway, Tromsø, Norway.
Blood Press ; 31(1): 270-283, 2022 12.
Article em En | MEDLINE | ID: mdl-36193001
What is the context? There is a relationship between high blood pressure and cardiovascular and kidney disease. Hypertension is defined as the level of blood pressure at which the benefits of treatment outweigh the risks of treatment. Hypertension is a risk factor for developing kidney disease, and kidney disease is a risk factor for developing hypertension. Today, kidney function is assessed by blood and urine samples (estimated glomerular filtration rate and urinary albumin excretion). However, today's blood and urine samples are not sensitive enough to capture kidney damage due to hypertension at a stage when prevention may be most effective.What is new? In this study, we assessed if urine orosomucoid and N-acetyl-ß-D-glucosaminidase (NAG) are more strongly associated with blood pressure and hypertension than urinary albumin excretion. In the population-based study of residents in Tromsø, Northern Norway, we assessed the relationship between the urine biomarkers and blood pressure, and the development of hypertension after 7 years. In the general population urine orosomucoid had a stronger relationship with blood pressure than urinary albumin excretion. After 7 years, urine orosomucoid had the strongest relationship with the development of hypertension. There were only varying and weak relationships between NAG, blood pressure and hypertension.What is the impact? Orosomucoid showed a stronger relationship with blood pressure and the development of hypertension than urinary albumin excretion. Urine orosomucoid may aid targeted prevention and treatment in hypertension, but further prospective clinical studies are needed to assess if orosomucoid is a clinically useful biomarker in hypertension.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Acetilglucosaminidase / Hipertensão Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Humans / Middle aged Idioma: En Revista: Blood Press Assunto da revista: ANGIOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Noruega

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Acetilglucosaminidase / Hipertensão Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Humans / Middle aged Idioma: En Revista: Blood Press Assunto da revista: ANGIOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Noruega