Anti-Toxoplasma gondii agent isolated from Orostachys malacophylla (Pallas) Fischer.
Exp Parasitol
; 242: 108397, 2022 Nov.
Article
em En
| MEDLINE
| ID: mdl-36195177
ABSTRACT
Botanical medicinal plants have aroused our interest to deal with Toxoplasmosis which can causes serious public health problems. Nipagic acid, gallic acid, ethyl gallate, phloretic acid, protocatechuic acid, methyl p-coumarate, arbutin, and homoprotocatechuic acid are first isolated from Orostachys malacophylla (Pallas) Fischer, their inhibition rate, survival rate, biochemical and viscera index are evaluated using gastric epithelia strain-1(GES-1). Among them, arbutin can effectively prolong the survival time of mice acutely infected with T. gondii, and exhibit the same curative effect as Spiramycin (Spi) group in terms of the glutathione (GSH) and malondialdehyde (MDA) content, alleviate hepatomegaly and splenomegaly. Structure-activity relationship (SAR) and molecular docking implies that phenolic hydroxyl group would be preferred for improvement of activity. In a summary, arbutin is a potential anti-T. gondii candidate for clinical application.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Toxoplasma
/
Espiramicina
Limite:
Animals
Idioma:
En
Revista:
Exp Parasitol
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China