End-of-life impact of concurrent diabetes mellitus and adrenal insufficiency as immune-related adverse events in an advanced non-small cell lung cancer patient.
Thorac Cancer
; 13(21): 3073-3075, 2022 11.
Article
em En
| MEDLINE
| ID: mdl-36195556
ABSTRACT
A 49-year-old man diagnosed with metastatic non-small cell lung cancer was treated with immune checkpoint inhibitor (ICI) combination therapy (nivolumab + ipilimumab) as first-line therapy. During the treatment course, the patient developed ICI-associated diabetes mellitus and adrenal insufficiency, and insulin and hydrocortisone replacement therapy (10 mg/day) were initiated for endocrine toxicity. Despite systemic treatment, the disease progressed. Near the end of the patient's life, he was repeatedly hospitalized for diabetic ketoacidosis and adrenal crisis because he could not physically administer insulin subcutaneously or self-administer oral hydrocortisone due to the deterioration of his general condition as a result of disease progression. This case report demonstrates that it is necessary to evaluate not only the impact of immune-related adverse events on short-term quality of life during ICI treatment but also on the patient's end-of-life care.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Insuficiência Adrenal
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Carcinoma Pulmonar de Células não Pequenas
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Diabetes Mellitus
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Insulinas
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Antineoplásicos Imunológicos
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Neoplasias Pulmonares
Limite:
Humans
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Male
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Middle aged
Idioma:
En
Revista:
Thorac Cancer
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Japão