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Steroid Sparing Therapies for Antineutrophil Cytoplasmic Autoantibodies Associated Vasculitis.
Ramirez, Maria Jose Zabala; Vu, Duy; Jain, Koyal.
Afiliação
  • Ramirez MJZ; UNC Kidney Center, Division of Nephrology and Hypertension, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Vu D; UNC Kidney Center, Division of Nephrology and Hypertension, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Jain K; UNC Kidney Center, Division of Nephrology and Hypertension, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address: koyal_jain@med.unc.edu.
Transfus Med Rev ; 36(4): 233-238, 2022 10.
Article em En | MEDLINE | ID: mdl-36207202
Antineutrophil cytoplasmic antibody (ANCA) associated vasculitis comprises a rare entity of disorders that affects primarily small and medium-sized blood vessels. Since first documented in 1897, we have come a long way trying to understand the pathogenesis and finding an optimal treatment regimen. The pathogenesis of ANCA vasculitis is not well understood and despite many advances in treatment, the morbidity and mortality remains high. Over the last decade, there have been many advancements toward elucidating the pathogenesis, optimizing current therapies, and discovering new medicines. Presently, one trend is aimed at minimizing the adverse effects of glucocorticoids by reducing their use without sacrificing efficacy and safety. A new medicine targeting the alternative complement system has emerged and intends to replace glucocorticoids. Here, we review three articles that describe these new trends in the management of ANCA vasculitis.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Anticorpos Anticitoplasma de Neutrófilos / Vasculite Associada a Anticorpo Anticitoplasma de Neutrófilos Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Transfus Med Rev Assunto da revista: HEMATOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Anticorpos Anticitoplasma de Neutrófilos / Vasculite Associada a Anticorpo Anticitoplasma de Neutrófilos Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Transfus Med Rev Assunto da revista: HEMATOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos