Function and regulation of thermosensitive ion channel TRPV4 in the immune system.
Curr Top Membr
; 89: 155-188, 2022.
Article
em En
| MEDLINE
| ID: mdl-36210148
ABSTRACT
Transient receptor potential vanilloid sub-type 4 (TRPV4) is a six transmembrane protein that acts as a non-selective Ca2+ channel. Notably, TRPV4 is present in almost all animals, from lower eukaryotes to humans and is expressed in diverse tissue and cell types. Accordingly, TRPV4 is endogenously expressed in several types of immune cells that represent both innate and adaptive immune systems of higher organism. TRPV4 is known to be activated by physiological temperature, suggesting that it acts as a molecular temperature sensor and thus plays a key role in temperature-dependent immune activation. It is also activated by diverse endogenous ligands, lipid metabolites, physical and mechanical stimuli. Both expression and function of TRPV4 in various immune cells, including T cells and macrophages, are also modulated by multiple pro- and anti-inflammatory compounds. The results from several laboratories suggest that TRPV4 is involved in the immune activation, a phenomenon with evolutionary significance. Because of its diverse engagement in the neuronal and immune systems, TRPV4 is a potential therapeutic target for several immune-related disorders.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Canais de Cátion TRPV
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Neurônios
Limite:
Animals
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Humans
Idioma:
En
Revista:
Curr Top Membr
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Índia