Thin-cap fibroatheroma and increased coronary intima-media thickness are associated with an altered balance of arginine metabolites.
Pol Arch Intern Med
; 133(2)2023 02 27.
Article
em En
| MEDLINE
| ID: mdl-36226830
ABSTRACT
INTRODUCTION:
Arginase inhibition increases plasma citrulline and citrulline / ornithine (C/O) ratio, and reduces plasma ornithine and ornithine / arginine (O/A) ratio in an animal model of myocardial infarction (MI).OBJECTIVES:
We hypothesized that the presence of thincap fibroatheroma (TCFA) in the culprit lesion and increased nonculprit intimamedia thickness of an infarctrelated artery (IRA) are associated with an altered balance of arginine metabolites. PATIENTS ANDMETHODS:
Arginine and its metabolites were measured using liquid chromatography and tandem mass spectrometry in 100 consecutive MI patients upon admission and at 6month followup. TCFA and adjacent to culprit lesion proximal and distal 10mm segments were assessed with optical coherence tomography in the acute phase. Twenty five patients without coronary lesions on angiography served as controls.RESULTS:
The C/O ratio increased 5.33 times (P <0.001), while the O/A ratio decreased 2.53 times (P <0.001) at the 6month followup, as compared with the acute phase of MI. The patients with (n = 75) vs without (n = 25) TCFA had lower C/O ratio by 29% (P = 0.003), while the mean intimamedia diameter of adjacent nonculprit region correlated with the followup O/A ratio (R = 0.337; P = 0.003). In a multivariable analysis, a higher acute phase C/O ratio was associated with a lower risk of TCFA presence (odds ratio, 0.978; 95% CI, 0.962-0.994; P = 0.006), whereas a higher followup O/A ratio correlated with larger intimamedia diameter of the adjacent segments (ß coefficient, 0.227; 95% CI for ß coefficient, 0.045-0.409; P = 0.018).CONCLUSIONS:
Enhanced arginase activity over nitric oxide synthase following ischemia was associated with the presence of TCFA in the culprit lesion, while a similar metabolic shift in the chronic phase correlated with a greater thickness of the intimamedia in the adjacent nonculprit IRA segments.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doença da Artéria Coronariana
/
Placa Aterosclerótica
/
Infarto do Miocárdio
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Pol Arch Intern Med
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Polônia