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The Potential Neuroprotective Effects of Extracts from Oat Seedlings against Alzheimer's Disease.
Lee, Won Seok; Lee, Hae-June; Yang, Ji Yeong; Shin, Hye-Lim; Choi, Sik-Won; Kim, Jong-Ki; Seo, Woo Duck; Kim, Eun Ho.
Afiliação
  • Lee WS; Department of Biochemistry, School of Medicine, Daegu Catholic University, Nam-gu, Daegu 42472, Korea.
  • Lee HJ; Division of Radiation Biomedical Research, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Korea.
  • Yang JY; Division of Crop Foundation, National Institute of Crop Science, Rural Development Administration, Jellabuk-do, Deokjin-gu, Jeonju 55365, Korea.
  • Shin HL; Forest Biomaterials Research Center, National Institute of Forest Science (NIFoS), Korea Forest Service (KFS), Jinju 52817, Korea.
  • Choi SW; Forest Biomaterials Research Center, National Institute of Forest Science (NIFoS), Korea Forest Service (KFS), Jinju 52817, Korea.
  • Kim JK; Department of Biomedical Engineering & Radiology, School of Medicine, Daegu Catholic University, Daegu 42472, Korea.
  • Seo WD; Division of Crop Foundation, National Institute of Crop Science, Rural Development Administration, Jellabuk-do, Deokjin-gu, Jeonju 55365, Korea.
  • Kim EH; Department of Biochemistry, School of Medicine, Daegu Catholic University, Nam-gu, Daegu 42472, Korea.
Nutrients ; 14(19)2022 Oct 02.
Article em En | MEDLINE | ID: mdl-36235754
The physiological or dietary advantages of germinated grains have been the subject of numerous discussions over the past decade. Around 23 million tons of oats are consumed globally, making up a sizeable portion of the global grain market. Oat seedlings contain more protein, beta-glucan, free amino acids, and phenolic compounds than seeds. The progressive neurodegenerative disorder of Alzheimer's is accompanied by worsening memory and cognitive function. A key indicator of this disorder is the unusual buildup of amyloid-beta protein (or Aß) in human brains. In this context, oat seedling extract (OSE) has been identified as a new therapeutic candidate for AD, due to its antioxidant activity and AD-specific mechanism of action. This study directly investigated how OSE affected AD and its impacts by examining the cognitive function and exploring the inflammatory response mechanism. The dried oat seedlings were grounded finely with a grinder, inserted with 50% fermented ethanol 10 times (w/v), and extracted by stirring for 10 h at 45 °C. After filtering the extract by 0.22 um filter, some of it was used for UHPLC analysis. The results indicated that the treatment with OSE protects against Aß25-35-induced cytotoxicity in BV2 cells. Tg-5Xfad AD mice had strong deposition of Aß throughout their brains, while WT mice did not exhibit any such deposition within their brains. A drastic reduction was observed in terms of numbers, as well as the size, of Aß plaques within Tg-5Xfad AD mice exposed to OSE. This study indicated OSE's neuroprotective impacts against neurodegeneration, synaptic dysfunction, and neuroinflammation induced by amyloid-beta. Our results suggest that OSE acts as a neuroprotective agent to combat AD-specific apoptotic cell death, neuroinflammation, amyloid-beta accumulation, as well as synaptic dysfunction in AD mice's brains. Furthermore, the study indicated that OSE treatment affects JNK/ERK/p38 MAPK signaling, with considerable inhibition in p-JNK, p-p38, and p-ERK levels seen in the brain of OSE-treated Tg-5Xfad AD mice.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fármacos Neuroprotetores / Beta-Glucanas / Doença de Alzheimer Limite: Animals / Humans Idioma: En Revista: Nutrients Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fármacos Neuroprotetores / Beta-Glucanas / Doença de Alzheimer Limite: Animals / Humans Idioma: En Revista: Nutrients Ano de publicação: 2022 Tipo de documento: Article