Solid-state cross-coupling reactions of insoluble aryl halides under polymer-assisted grinding conditions.
Faraday Discuss
; 241(0): 104-113, 2023 Jan 05.
Article
em En
| MEDLINE
| ID: mdl-36254741
ABSTRACT
In this study, polymer-assisted grinding (POLAG), a ball-milling technique based on the use of polymer additives, was applied to mechanochemical solid-state Suzuki-Miyaura cross-coupling reactions of insoluble aryl halides. We found that the efficiency of this challenging solid-state cross-coupling was improved by the addition of polytetrafluoroethylene (PTFE) as a POLAG additive under high-temperature ball-milling conditions. Our results suggest that POLAG is a promising approach for controlling the reactivity of insoluble substrates that are barely reactive under conventional solution-based conditions.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Faraday Discuss
Assunto da revista:
QUIMICA
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Japão