Comparison of a GLC-NPD method with a GLC-MS-SIM procedure for the determination of tilidine and its metabolites in plasma.
J Anal Toxicol
; 11(4): 144-8, 1987.
Article
em En
| MEDLINE
| ID: mdl-3626526
ABSTRACT
A gas liquid chromatographic method with nitrogen-phosphorus detection (GLC-NPD) is compared to a GLC-mass spectrometric determination employing selected ion monitoring (GLC-MS-SIM). These two methods of gas chromatographic separation were shown to be suitable for therapeutic monitoring of tilidine, nortilidine, and bisnortilidine in patients. The pharmacokinetic profile of tilidine was also studied in three normal humans after a single oral dose. Pharmacokinetic parameters such as Cmax, tmax, (t1/2) beta, AUC, AUMC, Vd beta, Cltot, beta, and MRT are derived from model independent pharmacokinetic techniques.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Tilidina
/
Ácidos Cicloexanocarboxílicos
Limite:
Adult
/
Humans
Idioma:
En
Revista:
J Anal Toxicol
Ano de publicação:
1987
Tipo de documento:
Article