Aryl hydrocarbon receptor knockout and antibody blockade of programmed cell death ligand1 increase co-stimulatory molecules on THP-1 and specific cytokine response of human T cells.

Sonnenburg, Anna; Stahlmann, Ralf; Kreutz, Reinhold; Peiser, Matthias

Sonnenburg, Anna; Stahlmann, Ralf; Kreutz, Reinhold; Peiser, Matthias.

Afiliação

Sonnenburg A; Charité-Universitätsmedizin Berlin, Institute for Clinical Pharmacology and Toxicology, Charitéplatz 1, 10117 Berlin, Germany; Freie Universität Berlin, Institute of Biochemistry, Thielallee 63, 14195 Berlin, Germany; German Federal Institute for Risk Assessment, Max-Dohrn-Str. 8-10, 10589 Berlin, G
Stahlmann R; Charité-Universitätsmedizin Berlin, Institute for Clinical Pharmacology and Toxicology, Charitéplatz 1, 10117 Berlin, Germany.
Kreutz R; Charité-Universitätsmedizin Berlin, Institute for Clinical Pharmacology and Toxicology, Charitéplatz 1, 10117 Berlin, Germany.
Peiser M; Freie Universität Berlin, Institute of Biochemistry, Thielallee 63, 14195 Berlin, Germany; German Federal Institute for Risk Assessment, Max-Dohrn-Str. 8-10, 10589 Berlin, Germany.

Toxicol In Vitro ; 86: 105502, 2023 Feb.

Article em En | MEDLINE | ID: mdl-36273671

Assuntos

Citocinas; Receptores de Hidrocarboneto Arílico; Humanos; Receptores de Hidrocarboneto Arílico/genética; Receptores de Hidrocarboneto Arílico/metabolismo; Citocinas/metabolismo; Células Dendríticas/metabolismo; Ativação Linfocitária; Apoptose; Antígeno B7-H1/genética; Antígeno B7-H1/metabolismo

Palavras-chave

AhR knockout; Anti-PD-L1; New approach methodologies; Skin sensitization; T cell activation; T cell assay

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Citocinas / Receptores de Hidrocarboneto Arílico Limite: Humans Idioma: En Revista: Toxicol In Vitro Assunto da revista: TOXICOLOGIA Ano de publicação: 2023 Tipo de documento: Article

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