Identification of a novel thyroid hormone receptor expressed in the mammalian central nervous system.
Science
; 237(4822): 1610-4, 1987 Sep 25.
Article
em En
| MEDLINE
| ID: mdl-3629259
ABSTRACT
A complementary DNA clone derived from rat brain messenger RNA has been isolated on the basis of homology to the human thyroid hormone receptor gene. Expression of this complementary DNA produces a high-affinity binding protein for thyroid hormones. Sequence analysis and the mapping of this gene to a distinct human genetic locus indicate the existence of multiple human thyroid hormone receptors. Messenger RNA from this gene is expressed in a tissue-specific fashion with highest levels in the central nervous system.
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Base de dados:
MEDLINE
Assunto principal:
Receptores dos Hormônios Tireóideos
/
Encéfalo
/
Proteínas de Ligação a DNA
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
1987
Tipo de documento:
Article