Access to N-CF3 Formamides by Reduction of N-CF3 Carbamoyl Fluorides.
Angew Chem Int Ed Engl
; 61(52): e202213829, 2022 12 23.
Article
em En
| MEDLINE
| ID: mdl-36308723
ABSTRACT
The departure into unknown chemical space is essential for the discovery of new properties and function. We herein report the first synthetic access to N-trifluoromethylated formamides. The method involves the reduction of bench-stable NCF3 carbamoyl fluorides and is characterized by operational simplicity and mildness, tolerating a broad range of functional groups as well as stereocenters. The newly made N-CF3 formamide motif proved to be highly robust and compatible with diverse chemical transformations, underscoring its potential as building block in complex functional molecules.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fluoretos
/
Formamidas
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Alemanha