Adenosine-Mimicking Derivatives of 3-Aminopyrazine-2-Carboxamide: Towards Inhibitors of Prolyl-tRNA Synthetase with Antimycobacterial Activity.

Pallabothula, Vinod Sukanth Kumar; Kerda, Marek; Juhás, Martin; Jandourek, Ondrej; Konecná, Klára; Bárta, Pavel; Paterová, Pavla; Zitko, Jan

Pallabothula, Vinod Sukanth Kumar; Kerda, Marek; Juhás, Martin; Jandourek, Ondrej; Konecná, Klára; Bárta, Pavel; Paterová, Pavla; Zitko, Jan.

Afiliação

Pallabothula VSK; Faculty of Pharmacy in Hradec Králové, Charles University, Ak. Heyrovského 1203/8, 500 05 Hradec Králové, Czech Republic.
Kerda M; Faculty of Pharmacy in Hradec Králové, Charles University, Ak. Heyrovského 1203/8, 500 05 Hradec Králové, Czech Republic.
Juhás M; Faculty of Pharmacy in Hradec Králové, Charles University, Ak. Heyrovského 1203/8, 500 05 Hradec Králové, Czech Republic.
Jandourek O; Faculty of Pharmacy in Hradec Králové, Charles University, Ak. Heyrovského 1203/8, 500 05 Hradec Králové, Czech Republic.
Konecná K; Faculty of Pharmacy in Hradec Králové, Charles University, Ak. Heyrovského 1203/8, 500 05 Hradec Králové, Czech Republic.
Bárta P; Faculty of Pharmacy in Hradec Králové, Charles University, Ak. Heyrovského 1203/8, 500 05 Hradec Králové, Czech Republic.
Paterová P; Department of Clinical Microbiology, University Hospital Hradec Králové, Sokolská 581, 500 05 Hradec Králové, Czech Republic.
Zitko J; Faculty of Pharmacy in Hradec Králové, Charles University, Ak. Heyrovského 1203/8, 500 05 Hradec Králové, Czech Republic.

Biomolecules ; 12(11)2022 10 26.

Article em En | MEDLINE | ID: mdl-36358911

Assuntos

Aminoacil-tRNA Sintetases; Mycobacterium tuberculosis; Humanos; Antituberculosos/farmacologia; Adenosina/farmacologia; Testes de Sensibilidade Microbiana

Palavras-chave

3-aminopyrazinamide; antibacterial; antimycobacterial; homology model; molecular dynamics; prolyl-tRNA synthetase; repurposing; tuberculosis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aminoacil-tRNA Sintetases / Mycobacterium tuberculosis Limite: Humans Idioma: En Revista: Biomolecules Ano de publicação: 2022 Tipo de documento: Article País de afiliação: República Tcheca

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