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Uncovering the Anticancer Potential of Polydatin: A Mechanistic Insight.
Shah, Muhammad Ajmal; Hamid, Ayesha; Faheem, Hafiza Ishmal; Rasul, Azhar; Baokbah, Tourki A S; Haris, Muhammad; Yousaf, Rimsha; Saleem, Uzma; Iqbal, Shabnoor; Alves, Maria Silvana; Khan, Zahid; Hussain, Ghulam; Alsharfi, Ifat; Khan, Haroon; Jeandet, Philippe.
Afiliação
  • Shah MA; Department of Pharmacy, Hazara University, Mansehra 21300, Pakistan.
  • Hamid A; Faculty of Pharmaceutical Sciences, Government College University, Faisalabad 38000, Pakistan.
  • Faheem HI; Faculty of Pharmaceutical Sciences, Government College University, Faisalabad 38000, Pakistan.
  • Rasul A; Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Pakistan.
  • Baokbah TAS; Department of Medical Emergency Services, College of Health Sciences-AlQunfudah, Umm Al-Qura University, Makkah 21955, Saudi Arabia.
  • Haris M; Faculty of Pharmaceutical Sciences, Universiteit Gent, Ghent 9000, Belgium.
  • Yousaf R; Faculty of Pharmaceutical Sciences, Government College University, Faisalabad 38000, Pakistan.
  • Saleem U; Faculty of Pharmaceutical Sciences, Government College University, Faisalabad 38000, Pakistan.
  • Iqbal S; Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Pakistan.
  • Alves MS; Laboratory of Cellular and Molecular Bioactivity, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Juiz de Fora 36036-900, Brazil.
  • Khan Z; Department of Pharmacognosy, Faculty of Pharmacy, Federal Urdu University of Arts, Science & Technology, Karachi 75300, Pakistan.
  • Hussain G; Department of Physiology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Pakistan.
  • Alsharfi I; Department of Biology, Jamoum University College, Umm Al-Qura University, Makkah 21955, Saudi Arabia.
  • Khan H; Department of Pharmacy, Abdul Wali Khan University Mardan, Mardan 23200, Pakistan.
  • Jeandet P; Research Unit Induced Resistance and Plant Bioprotection, University of Reims Champagne-Ardenne, USC INRAe 1488, 51100 Reims, France.
Molecules ; 27(21)2022 Oct 23.
Article em En | MEDLINE | ID: mdl-36364001
Polydatin or 3-O-ß-d-resveratrol-glucopyranoside (PD), a stilbenoid component of Polygonum cuspicadum (Polygonaceae), has a variety of biological roles. In traditional Chinese medicine, P. cuspicadum extracts are used for the treatment of infections, inflammation, and cardiovascular disorders. Polydatin possesses a broad range of biological activities including antioxidant, anti-inflammatory, anticancer, and hepatoprotective, neuroprotective, and immunostimulatory effects. Currently, a major proportion of the population is victimized with cervical lung cancer, ovarian cancer and breast cancer. PD has been recognized as a potent anticancer agent. PD could effectively inhibit the migration and proliferation of ovarian cancer cells, as well as the expression of the PI3K protein. The malignancy of lung cancer cells was reduced after PD treatments via targeting caspase 3, arresting cancer cells at the S phase and inhibiting NLRP3 inflammasome by downregulation of the NF-κB pathway. This ceases cell cycle, inhibits VEGF, and counteracts ROS in breast cancer. It also prevents cervical cancer by regulating epithelial-to-mesenchymal transition (EMT), apoptosis, and the C-Myc gene. The objective of this review is thus to unveil the polydatin anticancer potential for the treatment of various tumors, as well as to examine the mechanisms of action of this compound.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estilbenos / Neoplasias da Mama Limite: Female / Humans Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Paquistão

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estilbenos / Neoplasias da Mama Limite: Female / Humans Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Paquistão