Endostatin induces normalization of blood vessels in colorectal cancer and promotes infiltration of CD8+ T cells to improve anti-PD-L1 immunotherapy.

Chu, Xiao-Dong; Bao, Hui; Lin, Yu-Jian; Chen, Ruo-Xi; Zhang, Yi-Ran; Huang, Ting; He, Jia-Shuai; Huangfu, Shu-Chen; Pan, Yun-Long; Ding, Hui

Chu, Xiao-Dong; Bao, Hui; Lin, Yu-Jian; Chen, Ruo-Xi; Zhang, Yi-Ran; Huang, Ting; He, Jia-Shuai; Huangfu, Shu-Chen; Pan, Yun-Long; Ding, Hui.

Afiliação

Chu XD; Department of General Surgery, First Affiliated Hospital of Jinan University, Guangzhou, China.
Bao H; Department of Plastic Surgery, First Affiliated Hospital of Jinan University, Guangzhou, China.
Lin YJ; Department of General Surgery, First Affiliated Hospital of Jinan University, Guangzhou, China.
Chen RX; Department of Plastic Surgery, First Affiliated Hospital of Jinan University, Guangzhou, China.
Zhang YR; Department of General Surgery, First Affiliated Hospital of Jinan University, Guangzhou, China.
Huang T; Department of Clinical Pathology, First Affiliated Hospital of Jinan University, Guangzhou, China.
He JS; Department of General Surgery, First Affiliated Hospital of Jinan University, Guangzhou, China.
Huangfu SC; Department of General Surgery, First Affiliated Hospital of Jinan University, Guangzhou, China.
Pan YL; Department of General Surgery, First Affiliated Hospital of Jinan University, Guangzhou, China.
Ding H; Department of General Surgery, First Affiliated Hospital of Jinan University, Guangzhou, China.

Front Immunol ; 13: 965492, 2022.

Article em En | MEDLINE | ID: mdl-36389685

Assuntos

Neoplasias Colorretais; Endostatinas; Camundongos; Animais; Humanos; Endostatinas/metabolismo; Fator A de Crescimento do Endotélio Vascular/metabolismo; Inibidores de Checkpoint Imunológico; Linfócitos T CD8-Positivos/metabolismo; Imunoterapia; Fatores Imunológicos/metabolismo; Inibidores de Metaloproteinases de Matriz; Fator de Crescimento Transformador beta/metabolismo; Neoplasias Colorretais/tratamento farmacológico; Neoplasias Colorretais/metabolismo

Palavras-chave

CD8+ T cells; PD-L1 inhibitor; colorectal cancer; recombinant human endostatin; tumor vascular normalization

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Endostatinas Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Front Immunol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

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