Your browser doesn't support javascript.
loading
Kinetic evaluation and assessment of longitudinal changes in reference region and extracerebral [18F]MK-6240 PET uptake.
Fu, Jessie Fanglu; Lois, Cristina; Sanchez, Justin; Becker, J Alex; Rubinstein, Zoe B; Thibault, Emma; Salvatore, Andrew N; Sari, Hasan; Farrell, Michelle E; Guehl, Nicolas J; Normandin, Marc D; Fakhri, Georges El; Johnson, Keith A; Price, Julie C.
Afiliação
  • Fu JF; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.
  • Lois C; Harvard Medical School, Department of Radiology, Boston, MA, USA.
  • Sanchez J; Harvard Medical School, Department of Radiology, Boston, MA, USA.
  • Becker JA; Gordon Center for Medical Imaging, Massachusetts General Hospital, Boston, MA, USA.
  • Rubinstein ZB; Gordon Center for Medical Imaging, Massachusetts General Hospital, Boston, MA, USA.
  • Thibault E; Harvard Medical School, Department of Radiology, Boston, MA, USA.
  • Salvatore AN; Gordon Center for Medical Imaging, Massachusetts General Hospital, Boston, MA, USA.
  • Sari H; Gordon Center for Medical Imaging, Massachusetts General Hospital, Boston, MA, USA.
  • Farrell ME; Gordon Center for Medical Imaging, Massachusetts General Hospital, Boston, MA, USA.
  • Guehl NJ; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.
  • Normandin MD; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.
  • Fakhri GE; Harvard Medical School, Department of Radiology, Boston, MA, USA.
  • Johnson KA; Harvard Medical School, Department of Radiology, Boston, MA, USA.
  • Price JC; Harvard Medical School, Department of Radiology, Boston, MA, USA.
J Cereb Blood Flow Metab ; 43(4): 581-594, 2023 04.
Article em En | MEDLINE | ID: mdl-36420769
[18F]MK-6240 meningeal/extracerebral off-target binding may impact tau quantification. We examined the kinetics and longitudinal changes of extracerebral and reference regions. [18F]MK-6240 PET was performed in 24 cognitively-normal and eight cognitively-impaired subjects, with arterial samples in 13 subjects. Follow-up scans at 6.1 ± 0.5 (n = 25) and 13.3 ± 0.9 (n = 16) months were acquired. Extracerebral and reference region (cerebellar gray matter (CerGM)-based, cerebral white matter (WM), pons) uptake were evaluated using standardized uptake values (SUV90-110), spectral analysis, and distribution volume. Longitudinal changes in SUV90-110 were examined. The impact of reference region on target region outcomes, partial volume correction (PVC) and regional erosion were evaluated. Eroded WM and pons showed lower variability, lower extracerebral contamination, and lower longitudinal changes than CerGM-based regions. CerGM-based regions resulted larger cross-sectional effect sizes for group differentiation. Extracerebral signal was high in 50% of subjects and exhibited irreversible kinetics and nonsignificant longitudinal changes over one-year but was highly variable at subject-level. PVC resulted in higher variability in reference region uptake and longitudinal changes. Our results suggest that eroded CerGM may be preferred for cross-sectional, whilst eroded WM or pons may be preferred for longitudinal [18F]MK-6240 studies. For CerGM, erosion was necessary (preferred over PVC) to address the heterogenous nature of extracerebral signal.
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Disfunção Cognitiva Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Cereb Blood Flow Metab Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Disfunção Cognitiva Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Cereb Blood Flow Metab Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos