High-Throughput Metabolic Soft-Spot Identification in Liver Microsomes by LC/UV/MS: Application of a Single Variable Incubation Time Approach.

Zhu, Yanlin; Chen, Guiying; Zhang, Kerong; Chen, Chang; Chen, Weiqing; Zhu, Mingshe; Jiang, Hongliang

Zhu, Yanlin; Chen, Guiying; Zhang, Kerong; Chen, Chang; Chen, Weiqing; Zhu, Mingshe; Jiang, Hongliang.

Afiliação

Zhu Y; DMPK Department Shanghai ChemPartner, Shanghai, 201203, China.
Chen G; Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430074, China.
Zhang K; AB Sciex, Beijing 100015, China.
Chen C; Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430074, China.
Chen W; DMPK Department Shanghai ChemPartner, Shanghai, 201203, China.
Zhu M; MassDefect Technologies, Princeton, NJ 08540, USA.
Jiang H; Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430074, China.

Molecules ; 27(22)2022 Nov 20.

Article em En | MEDLINE | ID: mdl-36432161

Assuntos

Microssomos Hepáticos; Espectrometria de Massas em Tandem; Humanos; Microssomos Hepáticos/metabolismo; Espectrometria de Massas em Tandem/métodos; Cromatografia Líquida/métodos; Taxa de Depuração Metabólica; Ensaios de Triagem em Larga Escala

Palavras-chave

LC/UV/MS; Qtrap mass spectrometry; metabolic soft-spot; metabolite identification; triple-TOF mass spectrometry

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Microssomos Hepáticos / Espectrometria de Massas em Tandem Tipo de estudo: Diagnostic_studies / Prognostic_studies / Qualitative_research Limite: Humans Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google