The mitochondrial DNA HVI and HVII sequences and haplogroup distribution in a population sample from Vietnam.
Ann Hum Biol
; 49(7-8): 367-371, 2022 Dec.
Article
em En
| MEDLINE
| ID: mdl-36437685
ABSTRACT
BACKGROUND:
Mitochondrial DNA (mtDNA) analysis has been used in forensics and requires well-established population databases for statistical interpretations. However, high-quality mtDNA data from Vietnamese population samples have been limited.AIM:
To examine the mtDNA sequences and haplogroup compositions of a Vietnamese population to provide an mtDNA dataset that can further be used to construct a Vietnamese-specific reference database. SUBJECTS ANDMETHODS:
A total of 173 Vietnamese individuals were analysed for two hypervariable regions (HVI and HVII) of mtDNA. Forensic parameters were calculated and haplogroup assignment was performed based on the resulting mtDNA haplotypes. Genetic relationships between the Vietnamese and other Asian populations were investigated through principal component analysis (PCA) and pairwise Fst.RESULTS:
The Vietnamese population sample consisted of 145 different haplotypes with a random match probability of 0.96%, a power of discrimination of 0.9904, and a haplotype diversity of 0.9962. The samples were assigned to 83 haplogroups that were commonly reported in Asia. PCA and pairwise Fst revealed close relationships of the Vietnamese population with other Asian populations, especially with populations in proximity.CONCLUSION:
The results from this study can contribute to the current genetic information content as a supplementary mtDNA reference dataset for forensic investigations and phylogenetic research.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
DNA Mitocondrial
/
Genética Populacional
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Ann Hum Biol
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Vietnã