SCYL3, as a novel binding partner and regulator of ROCK2, promotes hepatocellular carcinoma progression.

Lei, Martina Mang Leng; Leung, Carmen Oi Ning; Lau, Eunice Yuen Ting; Leung, Rainbow Wing Hei; Ma, Victor Wan San; Tong, Man; Lu, Yin Ying; Huang, Chen Yang; Zhu, Qiao Hua; Ng, Irene Oi Lin; Ma, Stephanie; Lee, Terence Kin Wah

Lei, Martina Mang Leng; Leung, Carmen Oi Ning; Lau, Eunice Yuen Ting; Leung, Rainbow Wing Hei; Ma, Victor Wan San; Tong, Man; Lu, Yin Ying; Huang, Chen Yang; Zhu, Qiao Hua; Ng, Irene Oi Lin; Ma, Stephanie; Lee, Terence Kin Wah.

Afiliação

Lei MML; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong.
Leung CON; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong.
Lau EYT; Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong.
Leung RWH; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong.
Ma VWS; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong.
Tong M; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.
Lu YY; Comprehensive Liver Cancer Center, The Fifth Medical Center of PLA General Hospital, Beijing, China.
Huang CY; Comprehensive Liver Cancer Center, The Fifth Medical Center of PLA General Hospital, Beijing, China.
Zhu QH; Department of Interventional Radiology and Oncology, Shunde Hospital, Southern Medical University, Shunde, China.
Ng IOL; Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong.
Ma S; State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong.
Lee TKW; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.

JHEP Rep ; 5(1): 100604, 2023 Jan.

Article em En | MEDLINE | ID: mdl-36440258

Palavras-chave

CHX, cycloheximide; EV, empty vector; GEO, Gene Expression Omnibus; HCC, hepatocellular carcinoma; HRD motif, histidine-arginine-aspartic acid motif; HTVI, hydrodynamic tail vein injection; Hepatocellular carcinoma; MLC2, myosin light chain 2; Metastasis; NTC, non-target control; OE, overexpression; Protein stability; ROCK2; ROCK2, Rho kinase 2; SB, sleeping beauty; SCYL3; SCYL3 OE, SCYL3-overexpressing; SCYL3, SCY1-like pseudokinase 3; SCYL3-ΔC, SCYL3 mutant with deletion of the C-terminal domain; TCGA, The Cancer Genome Atlas; qPCR, quantitative PCR; sg, single-guide; sh, short-hairpin

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: JHEP Rep Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Hong Kong

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: JHEP Rep Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Hong Kong